Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Elaine Del Nery"'
Autor:
Elise Dumas, Beatriz Grandal Rejo, Paul Gougis, Sophie Houzard, Judith Abécassis, Floriane Jochum, Benjamin Marande, Annabelle Ballesta, Elaine Del Nery, Thierry Dubois, Samar Alsafadi, Bernard Asselain, Aurélien Latouche, Marc Espie, Enora Laas, Florence Coussy, Clémentine Bouchez, Jean-Yves Pierga, Christine Le Bihan-Benjamin, Philippe-Jean Bousquet, Judicaël Hotton, Chloé-Agathe Azencott, Fabien Reyal, Anne-Sophie Hamy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Between 30% and 70% of patients with breast cancer have pre-existing chronic conditions, and more than half are on long-term non-cancer medication at the time of diagnosis. Preliminary epidemiological evidence suggests that some non-cancer m
Externí odkaz:
https://doaj.org/article/ef9fd876d61b484797a07b0a5cc370ea
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract High content screening (HCS) is a technology that automates cell biology experiments at large scale. A High Content Screen produces a high amount of microscopy images of cells under many conditions and requires that a dedicated image and dat
Externí odkaz:
https://doaj.org/article/73aeadb24ee24e37a3d2b83f9f5a1b45
Autor:
Alexis Lamiable, Tiphaine Champetier, Francesco Leonardi, Ethan Cohen, Peter Sommer, David Hardy, Nicolas Argy, Achille Massougbodji, Elaine Del Nery, Gilles Cottrell, Yong-Jun Kwon, Auguste Genovesio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Biological sciences, drug discovery and medicine rely heavily on cell phenotype perturbation and microscope observation. However, most cellular phenotypic changes are subtle and thus hidden from us by natural cell variability: two cells in t
Externí odkaz:
https://doaj.org/article/998060b82d274222910792db9a50f65a
Autor:
Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-9 (2022)
Abstract Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotyp
Externí odkaz:
https://doaj.org/article/6015f6327eea48c4a7d33a5c1b253f8b
Autor:
Romain Fevre, Gaëtan Mary, Nadia Vertti-Quintero, Aude Durand, Raphaël F.-X. Tomasi, Elaine Del Nery, Charles N. Baroud
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106651- (2023)
Summary: Culturing and screening cells in microfluidics, particularly in three-dimensional formats, has the potential to impact diverse areas from fundamental biology to cancer precision medicine. Here, we use a platform based on anchored droplets fo
Externí odkaz:
https://doaj.org/article/6643fa5d831946cbbef6bb44e4278d1b
Autor:
Ethan Cohen, Maxime Corbe, Cláudio A. Franco, Francisca F. Vasconcelos, Franck Perez, Elaine Del Nery, Guillaume Bollot, Auguste Genovesio
Publikováno v:
Biological Imaging, Vol 3 (2023)
Drug discovery uses high throughput screening to identify compounds that interact with a molecular target or that alter a phenotype favorably. The cautious selection of molecules used for such a screening is instrumental and is tightly related to the
Externí odkaz:
https://doaj.org/article/85d3f2e86ce640d79c502ef9afe3ca38
The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
Autor:
Emmanuel Laplantine, Christine Chable-Bessia, Anne Oudin, Jitendryia Swain, Adèle Soria, Peggy Merida, Manon Gourdelier, Sarra Mestiri, Indira Besseghe, Erwan Bremaud, Aymeric Neyret, Sebastien Lyonnais, Cyril Favard, Philippe Benaroch, Mathieu Hubert, Olivier Schwartz, Maryse Guerin, Anne Danckaert, Elaine Del Nery, Delphine Muriaux, Robert Weil
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105066- (2022)
Summary: Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatmen
Externí odkaz:
https://doaj.org/article/b6e838e482d64a02b2c8d86937fd4c8f
Autor:
Eleonora Grisard, Nathalie Nevo, Aurianne Lescure, Sebastian Doll, Maxime Corbé, Mabel Jouve, Gregory Lavieu, Alain Joliot, Elaine Del Nery, Lorena Martin‐Jaular, Clotilde Théry
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Eukaryotic cells, including cancer cells, secrete highly heterogeneous populations of extracellular vesicles (EVs). EVs could have different subcellular origin, composition and functional properties, but tools to distinguish between EV subty
Externí odkaz:
https://doaj.org/article/1595545f8d25444cabe89f29779efd30
Autor:
Mathilde Vinet, Samyuktha Suresh, Virginie Maire, Clarisse Monchecourt, Fariba Némati, Laetitia Lesage, Fabienne Pierre, Mengliang Ye, Auriane Lescure, Amélie Brisson, Didier Meseure, André Nicolas, Guillem Rigaill, Elisabetta Marangoni, Elaine Del Nery, Sergio Roman‐Roman, Thierry Dubois
Publikováno v:
Cancer Medicine, Vol 8, Iss 5, Pp 2414-2428 (2019)
Abstract TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted therapy yet exists. Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of
Externí odkaz:
https://doaj.org/article/e38d40999951432e94d1e8844dc31f54
Autor:
Patrycja Kozik, Marine Gros, Daniel N. Itzhak, Leonel Joannas, Sandrine Heurtebise-Chrétien, Patrycja A. Krawczyk, Pablo Rodríguez-Silvestre, Andrés Alloatti, Joao Gamelas Magalhaes, Elaine Del Nery, Georg H.H. Borner, Sebastian Amigorena
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107905- (2020)
Summary: Cross-presentation of antigens by dendritic cells (DCs) is critical for initiation of anti-tumor immune responses. Yet, key steps involved in trafficking of antigens taken up by DCs remain incompletely understood. Here, we screen 700 US Food
Externí odkaz:
https://doaj.org/article/f41e73c206eb498a84df86376d83caea