Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elaine Cowan"'
Autor:
Alexandros Karagiannopoulos, Efraim Westholm, Jones K. Ofori, Elaine Cowan, Jonathan L.S. Esguerra, Lena Eliasson
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106555- (2023)
Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting En
Externí odkaz:
https://doaj.org/article/68be0083631b4762bbc8a922b0b0f138
Autor:
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz:
https://doaj.org/article/1b6d5184407e4059bd119a1db2f0c8ba
Autor:
Luis Rodrigo Cataldo, Qian Gao, Lidia Argemi-Muntadas, Ondrej Hodek, Elaine Cowan, Sergey Hladkou, Sevda Gheibi, Peter Spégel, Rashmi B. Prasad, Lena Eliasson, Camilla Scheele, Malin Fex, Hindrik Mulder, Thomas Moritz
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101629- (2022)
Objective: Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. Despite that EPDR1 is expressed in human pancreatic β-cells and that gluco
Externí odkaz:
https://doaj.org/article/020d789591674d79befd05b5d255d820
Publikováno v:
Endocrinology. 164
Type 2 diabetes (T2D) develops due to insulin resistance and an inability of the pancreatic β-cells to increase secretion of insulin and reduce elevated blood glucose levels. Diminished β-cell function and mass have been implicated in impaired β-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf8c55cfb9bfda3b68d8684b6059302
https://doi.org/10.1210/endocr/bqad040
https://doi.org/10.1210/endocr/bqad040
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628065
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30db03dc704d0f21d937d195c7ed97ca
https://doi.org/10.1007/978-1-0716-2807-2_8
https://doi.org/10.1007/978-1-0716-2807-2_8
Autor:
Mohammad, Barghouth, Yingying, Ye, Alexandros, Karagiannopoulos, Yunhan, Ma, Elaine, Cowan, Rui, Wu, Lena, Eliasson, Erik, Renström, Cheng, Luan, Enming, Zhang
Publikováno v:
Cell calcium. 108
Voltage-gated Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a251a371568ac8bffd41427aed69e791
https://pubmed.ncbi.nlm.nih.gov/36347081
https://pubmed.ncbi.nlm.nih.gov/36347081
Autor:
Jessica Harding, Maria Paula Macedo, Bishal Gyawali, Andreas Kjaer, Daniel Esteban Coral Candelo, Morten Hasselstrøm Jensen, Sonya Deschênes, Aase Handberg, Alexander Y. Mayorov, Jens Juul Holst, Jonathan Mertens, Fleur Levrat-Guillen, Paola Parra Ramírez, Bolette Hartmann, Jon Mabley, Jayakumar Vadakekolathu, Ole Hejlesen, Soulef Maandi, Frank Otto, ANTHONY PIRON, Anna Zheleznyakova, Elaine Cowan, Khrystyna Moskva, Turkuler Ozgumus, Marija Petkovic
Publikováno v:
Diabetologia. 63:1-485
Background and aims: We have previously shown that interrupting prolonged periods of sitting with short, frequent light-intensity walking activity improves postprandial glucose levels in people with and at risk of Type 2 Diabetes. However, no researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e0162a265eb8c947788fe7cc31aed0a
https://doi.org/10.1007/s00125-020-05221-5
https://doi.org/10.1007/s00125-020-05221-5
Autor:
David G. Nicholls, Anya Wernersson, Vamsi K. Mootha, Peter Spégel, Kimberli J. Kamer, H. Barnard, Elaine Cowan, Neelanjan Vishnu, Annika Bagge, Alexander Hamilton, Malin Fex, Anders Tengholm, Hindrik Mulder, Y. Sancak
Publikováno v:
Molecular Metabolism, Vol 51, Iss, Pp 101239-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Transport of Ca2+ into pancreatic β cell mitochondria facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. Recent establishment of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896292a8a6b0f86d39660eb55ca5d9ff
http://www.sciencedirect.com/science/article/pii/S2212877821000843
http://www.sciencedirect.com/science/article/pii/S2212877821000843
Autor:
Alexander Bowen, Rodrigo Cataldo Buscunan, Alexander Hamilton, Claire L. Lyons, Gaurav Verma, Hindrik Mulder, Malin Fex, Jonathan L.S. Esguerra, Alexandros Karagiannopoulos, Elaine Cowan
We previously reported that transcription factor B1 mitochondrial (TFB1M) is involved in the pathogenesis of type 2 diabetes (T2D) owing to mitochondrial dysfunction. Here, we describe that dimethyladenosine transferase 1 homolog (DIMT1), a homologue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4781b4a9935b4871648f494d21d8f345
https://doi.org/10.1101/2020.09.27.313262
https://doi.org/10.1101/2020.09.27.313262
Publikováno v:
Diabetologia
Aim/hypothesis Human enteroviral infections are suggested to be associated with type 1 diabetes. However, the mechanism by which enteroviruses can trigger disease remains unknown. The present study aims to investigate the impact of enterovirus on aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c79e3bdeb1c5284cd0a3c46032eefa1
https://pubmed.ncbi.nlm.nih.gov/32676816
https://pubmed.ncbi.nlm.nih.gov/32676816