Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.

Autor: Elaine C Thomas, Jennifer H Gunter, Julie A Webster, Nicole L Schieber, Viola Oorschot, Robert G Parton, Jonathan P Whitehead

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51096 (2012)

We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide biosynthesis, clustered into macrostructures in response to decreased nucleotide levels and that there were differences betwee

Externí odkaz: https://doaj.org/article/32c27f19f4124a7386c5b58766700fe7

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Autor: David Carling, Alexander Gray, Hadi Al-Hasani, Kate J. Heesom, Sharon C. Hook, D. Grahame Hardie, Alexandra Chadt, Jeremy M. Tavaré, Elaine C. Thomas

Publikováno v: Biochemical Journal
Thomas, E, Hook, S C, Grey, A, Chadt, A, Carling, D, Al-Hasani, H, Heesom, K J, Hardie, G & Tavare, J 2018, ' Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity ', Biochemical Journal, vol. 475, no. 18, 475, pp. 2969-2983 . https://doi.org/10.1042/BCJ20180475

AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation of a myriad of downstream targets. One target is TBC1D1 a Rab-GTPase-activating protein that regulates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b460c96ce5d44a36db03753f34791d34
http://europepmc.org/articles/PMC6156765

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

Autor: Joya Pawade, Douglas J. E. Elder, Muhammed Sohail, Margaret T May, Emma E. Vincent, Lois Phillips, Jeremy M. Tavaré, C. Morgan, Martin R. Hetzel, Elaine C. Thomas

Publikováno v: British Journal of Cancer

Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells. Akt activation involves the phosphorylation of two residues: threonine 308 (Thr308) in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38172bc5d9b4cde7073ce917c07f3a25
https://doi.org/10.1038/bjc.2011.132

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

Autor: Douglas J. E. Elder, Alexey Sergushichev, Thierry Ntimbane, Ekaterina Loginicheva, Emma E. Vincent, Gaëlle Bridon, Takla Griss, Elaine C. Thomas, Luc Choinière, Arnim Pause, Breanna R. Flynn, Maxim N. Artyomov, Bozena Samborska, Thomas C. Raissi, Julianna Blagih, Jeremy M. Tavaré, Daina Avizonis, Russell G. Jones, Paula P. Coelho, Marie-Claude Gingras

Publikováno v: Vincent, E E, Sergushichev, A, Griss, T, Gingras, M C, Samborska, B, Ntimbane, T, Coelho, P P, Blagih, J, Raissi, T C, Choinière, L, Bridon, G, Loginicheva, E, Flynn, B R, Thomas, E C, Tavaré, J M, Avizonis, D, Pause, A, Elder, D J E, Artyomov, M N & Jones, R G 2015, ' Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth ', Molecular Cell, vol. 60, no. 2, pp. 195-207 . https://doi.org/10.1016/j.molcel.2015.08.013

Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used combined transcriptional-metabolomic network analysis to identify metabolic pathways that support glucose-independent tumor cell proliferation. We found that gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de91fd519ddc9d2f66102d7d42f6e761
https://research-information.bris.ac.uk/en/publications/7e24d67e-0600-4212-93d4-3bd1a2f4a636

Insulin and Oleate Promote Translocation of Inosine-5′ Monophosphate Dehydrogenase to Lipid Bodies

Autor: David E. James, Richard J. Simpson, Frank R. Collart, Elaine C. Thomas, Michelle M. Hill, Jonathan P. Whitehead, Lisa M. Connolly, Fiona Simpson

Publikováno v: Traffic. 5:739-749

In the present study we identify inosine-5' monophosphate dehydrogenase (IMPDH), a key enzyme in de novo guanine nucleotide biosynthesis, as a novel lipid body-associated protein. To identify new targets of insulin we performed a comprehensive 2-DE a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e99f71b7a22989a5fb865207a412e844
https://doi.org/10.1111/j.1600-0854.2004.00217.x