Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elaine C Chen"'
Autor:
Elaine C Chen, Samuel Rubinstein, Cinque Soto, Robin G Bombardi, Samuel B Day, Luke Myers, Alexey Zaytsev, Mahsa Majedi, R Frank Cornell, James E Crowe
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235713 (2020)
Immunoglobulin light chain amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is caused by a misfolded light chain produced by a clonal population of plasma cells. Disease status currently is defined by measuring the absolute
Externí odkaz:
https://doaj.org/article/1e0d12326e3f4900985b6fa03650e87a
Autor:
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Philipp A. Ilinykh, Elad Binshtein, Kai Huang, Luke Myers, Stefano Bonissone, Samuel Day, Chandrahaas R. Kona, Andrew Trivette, Joseph X. Reidy, Rachel E. Sutton, Christopher Gainza, Summer Diaz, Jazmean K. Williams, Christopher N. Selverian, Edgar Davidson, Erica Ollmann Saphire, Benjamin J. Doranz, Natalie Castellana, Alexander Bukreyev, Robert H. Carnahan, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112370- (2023)
Summary: Understanding the human antibody response to emerging viral pathogens is key to epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective antigen is poorly defined, we perform deep paired heavy- and light-cha
Externí odkaz:
https://doaj.org/article/bf9215d14449450b85f7bee1f2faf9da
Autor:
Cinque Soto, Robin G. Bombardi, Morgan Kozhevnikov, Robert S. Sinkovits, Elaine C. Chen, Andre Branchizio, Nurgun Kose, Samuel B. Day, Mark Pilkinton, Madhusudan Gujral, Simon Mallal, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107882- (2020)
Summary: The collection of T cell receptors (TCRs) generated by somatic recombination is large but unknown. We generate large TCR repertoire datasets as a resource to facilitate detailed studies of the role of TCR clonotypes and repertoires in health
Externí odkaz:
https://doaj.org/article/98fd6f3e962f414a88007480882b26d2
Autor:
Seth J. Zost, Matthew B. Frieman, Allison J. Greaney, Yueh-Ming Loo, Marisa McGrath, Elad Binshtein, Stuart Weston, James Brett Case, James Logue, James E. Crowe, Robert H. Carnahan, Helen Bright, Pei Yong Shi, Kevin M Tuffy, Tyler Brady, Rachel E. Sutton, Tyler N. Starr, Patrick M. McTamney, Jesse D. Bloom, Elaine C. Chen, Mark T. Esser, Adam S. Dingens, Xianwen Zhang, Rita E. Chen, Pavlo Gilchuk, Rachel S. Nargi, Jessica Rodriguez, Xuping Xie, Christopher Gainza, Erica Armstrong, Jinhui Dong, Michael S. Diamond
Publikováno v:
Nature Microbiology. 6:1233-1244
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies-AZD8895 and AZD1061-which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::114561dbf6a737a26c61cfe4093fda61
https://doi.org/10.1038/s41564-021-00972-2
https://doi.org/10.1038/s41564-021-00972-2
Autor:
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Philipp A. Ilinykh, Elad Binshtein, Kai Huang, Luke Myers, Stefano Bonissone, Samuel Day, Chandrahaas R. Kona, Andrew Trivette, Joseph X. Reidy, Rachel E. Sutton, Christopher Gainza, Summer Monroig, Edgar Davidson, Erica Ollmann Saphire, Benjamin J. Doranz, Natalie Castellana, Alexander Bukreyev, Robert H. Carnahan, James E. Crowe
SUMMARYUnderstanding the human antibody response to emerging viral pathogens is key to epidemic preparedness. As the size of the B cell response to a pathogenic virus protective antigen is undefined, we performed deep paired heavy and light chain seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c031083e2c67b85af42a3d437ac6fcd
https://doi.org/10.1101/2022.01.12.476089
https://doi.org/10.1101/2022.01.12.476089
Autor:
Nidhi, Gupta, Susanna, Marquez, Cinque, Soto, Elaine C, Chen, Magnolia L, Bostick, Ulrik, Stervbo, Andrew, Farmer
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621141
Methods Mol Biol
Methods Mol Biol
During the course of an immune response to a virus such as influenza, B cells undergo activation, clonal expansion, isotype switching, and somatic hypermutation (SHM). Members of an antigen-experienced B-cell clone can have different sequence feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa6b644c6750bd794ffb24ac0fc981
https://doi.org/10.1007/978-1-0716-2115-8_19
https://doi.org/10.1007/978-1-0716-2115-8_19
Autor:
Pavlo Gilchuk, Iuliia M. Gilchuk, Natalie J. Thornburg, Cinque Soto, Hannah L. Turner, Sheng Li, Robin G. Bombardi, Jinhui Dong, Naveenchandra Suryadevara, James E. Crowe, Elaine C. Chen, Rachel S. Nargi, Jessica A. Finn, Robert H. Carnahan, Sandhya Bangaru, Ryan P. Irving, Jonna B. Westover, Seth J. Zost, Nurgun Kose, Andrew B. Ward, Rachel E. Sutton
Publikováno v:
J Clin Invest
Broadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac5d3d7701f588a04bd97406e9849eb
https://europepmc.org/articles/PMC8321569/
https://europepmc.org/articles/PMC8321569/
Autor:
Jinhui, Dong, Seth J, Zost, Allison J, Greaney, Tyler N, Starr, Adam S, Dingens, Elaine C, Chen, Rita E, Chen, James Brett, Case, Rachel E, Sutton, Pavlo, Gilchuk, Jessica, Rodriguez, Erica, Armstrong, Christopher, Gainza, Rachel S, Nargi, Elad, Binshtein, Xuping, Xie, Xianwen, Zhang, Pei-Yong, Shi, James, Logue, Stuart, Weston, Marisa E, McGrath, Matthew B, Frieman, Tyler, Brady, Kevin M, Tuffy, Helen, Bright, Yueh-Ming, Loo, Patrick M, McTamney, Mark T, Esser, Robert H, Carnahan, Michael S, Diamond, Jesse D, Bloom, James E, Crowe
Publikováno v:
bioRxiv
The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the genetic and structural basis for SARS-CoV-2 neutralization, we determined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92f841c2879a4ab576f2b4ca6f91bd06
https://pubmed.ncbi.nlm.nih.gov/33532768
https://pubmed.ncbi.nlm.nih.gov/33532768
Autor:
Pavlo Gilchuk, Adrian Guthals, Stefano R. Bonissone, Jared B. Shaw, Philipp A. Ilinykh, Kai Huang, Robin G. Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson, Elaine C. Chen, Bronwyn M. Gunn, Galit Alter, Erica Ollmann Saphire, Benjamin J. Doranz, Alexander Bukreyev, Larry Zeitlin, Natalie Castellana, James E. Crowe
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa. The largest Ebola virus disease (EVD) epidemic to date in 2013-2016 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a267fa65767ae369eda21aecdc0d7
http://europepmc.org/articles/PMC8322977
http://europepmc.org/articles/PMC8322977
Autor:
Carly R. Cabel, Pavlo Gilchuk, Rachel E. Sutton, Elad Binshtein, Rita E. Chen, Robert H. Carnahan, Luke Myers, Jazmean K. Williams, Naveenchandra Suryadevara, Curtis A. Thorne, Elaine C. Chen, Emma S. Winkler, Samuel Day, Edgar Davidson, Seth J. Zost, Jessica Rodriguez, Shuaizhi Li, James E. Crowe, Andrew Trivette, Benjamin J. Doranz, Samuel K. Campos, Michael S. Diamond
Publikováno v:
bioRxiv
Cell Reports
Cell Reports, Vol 36, Iss 8, Pp 109604-(2021)
Cell Reports
Cell Reports, Vol 36, Iss 8, Pp 109604-(2021)
Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases as well as healthy individuals. Here we identify 37 public clonotypes in memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e63dc8c82a56757249a8ed233d605c
https://doi.org/10.1101/2021.05.02.442326
https://doi.org/10.1101/2021.05.02.442326