Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elaine Barrie"'
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2.
Autor:
M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65689 (2013)
Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift ass
Externí odkaz:
https://doaj.org/article/d0694d58cc464620a9a172b566b0062e
Autor:
Elaine Barrie, S, Eno-Amooquaye, Ebun, Hardcastle, Anthea, Platt, Georgina, Richards, Juliet, Bedford, David, Workman, Paul, Aherne, Wynne, Mittnacht, Sibylle, Garrett, Michelle D
Publikováno v:
In Analytical Biochemistry 2003 320(1):66-74
Autor:
Lloyd R. Kelland, Florence I. Raynaud, Paul Workman, Michelle D. Garrett, Suzanne A. Eccles, S. Elaine Barrie, Steven R. Whittaker, Peter Fischer, David P. Lane, L. Brunton, Steven J. McClue, Michael I. Walton, Paul Rogers, Melanie Valenti, Simon J Clarke
Publikováno v:
Clinical Cancer Research. 11:4875-4887
Purpose: To investigate pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine, and CYC202 (R-roscovitine; seliciclib) in the HCT116 human colon carcinoma model. Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ed0b9c5d0f89643e44dc33025ec953
https://doi.org/10.1158/1078-0432.ccr-04-2264
https://doi.org/10.1158/1078-0432.ccr-04-2264
Autor:
Isaac M. Westwood, Elaine Barrie, Nathan J. Brown, Ian Collins, Swen Hoelder, Michelle D. Garrett, G. Wynne Aherne, Rob L. M. van Montfort, Julian Blagg, M. Cris Silva-Santisteban, Rosemary Burke, Meirion Richards, Antony W. Oliver, Keith Jones, Amin Mirza, Sam Peacock, Craig McAndrew, Kathy Boxall
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65689 (2013)
PLoS ONE
PLoS ONE
Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd9b93249cd715ccb6133a1fc1275a3
http://europepmc.org/articles/PMC3680490?pdf=render
http://europepmc.org/articles/PMC3680490?pdf=render
Autor:
John Houghton, Martin G. Rowlands, S. Elaine Barrie, John Mann, Michael Jarman, Margret Haase-Held, Maria Hatzis
Publikováno v:
Journal of Enzyme Inhibition. 8:17-23
Some 4-fluorinated analogues of 3-oxo-delta 4 steroids and 4-cyano derivatives of progesterone and androstenedione were evaluated as inhibitors of steroid 5 alpha-reductase activity. Inhibitors of this enzyme may be useful in treating prostatic cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1895c1b65e3b37dfdaad6b095b1fae88
https://doi.org/10.3109/14756369409040773
https://doi.org/10.3109/14756369409040773
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ebcc4921289d27062a0550abd156b9
https://doi.org/10.1002/chin.199921191
https://doi.org/10.1002/chin.199921191
Publikováno v:
Nature clinical practice. Urology. 5(11)
Androgen receptor (AR) signaling has a key role in the pathogenesis of prostate cancer. AR gene amplification, AR overexpression, and activating mutations in the AR occur more frequently as castration-resistant prostate cancer (CRPC) evolves, with in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88a20450006d39b7eb6c37085e03e42
https://pubmed.ncbi.nlm.nih.gov/18985049
https://pubmed.ncbi.nlm.nih.gov/18985049
Autor:
Michelle D. Garrett, Laurence H. Pearl, K. Boxall, Angela Paul, Antony W. Oliver, S. Elaine Barrie, G. Wynne Aherne, Sibylle Mittnacht
Publikováno v:
The EMBO journal. 25(13)
The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine-glutamine/threonine-glutamine cluster domain (SCD), by ATM. The phosphorylated SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2c8479f6603978ad7c54669939b3be
https://pubmed.ncbi.nlm.nih.gov/16794575
https://pubmed.ncbi.nlm.nih.gov/16794575
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(6)
R115777 (Zarnestra) is a farnesyl protein transferase inhibitor currently undergoing worldwide clinical trials. As acquired drug resistance may limit the efficacy of the drug, a model of acquired resistance has been established in vitro by continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9684909be0c275feda5e25adb302de67
https://pubmed.ncbi.nlm.nih.gov/12060646
https://pubmed.ncbi.nlm.nih.gov/12060646