Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Elaine A Elion"'
Autor:
Francis W Farley, Ryan R McCully, Paul B Maslo, Lu Yu, Mark A Sheff, Homayoun Sadeghi, Elaine A Elion
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0289339 (2023)
Ste5 is a prototype of scaffold proteins that regulate activation of mitogen-activated protein kinase (MAPK) cascades in all eukaryotes. Ste5 associates with many proteins including Gβγ (Ste4), Ste11 MAPKKK, Ste7 MAPKK, Fus3 and Kss1 MAPKs, Bem1, C
Externí odkaz:
https://doaj.org/article/e49beb71f216481a93810bd2dcbcf5b1
Autor:
Francis W. Farley, Ryan R. McCully, Paul B. Maslo, Lu Yu, Mark A. Sheff, Homayoun Sadeghi, Elaine A. Elion
Ste5 is a prototype of scaffold proteins that regulate activation of mitogen-activated protein kinase (MAPK) cascades in all eukaryotes. Ste5 associates with many proteins including Gβγ (Ste4), Ste11 MAPKKK, Ste7 MAPKK, Fus3 and Kss1 MAPKs, Bem1, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12890376e4f769fa2e127dc4a11363fa
https://doi.org/10.1101/2022.08.19.503794
https://doi.org/10.1101/2022.08.19.503794
Publikováno v:
Biochemistry and Cell Biology. 94:109-128
Careful control of the available pool of the MAPK scaffold Ste5 is important for mating-pathway activation and the prevention of inappropriate mating differentiation in haploid Saccharomyces cerevisiae. Ste5 shuttles constitutively through the nucleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95e720259e7e0217d1c5ef3bc875597
https://doi.org/10.1139/bcb-2015-0101
https://doi.org/10.1139/bcb-2015-0101
Publikováno v:
Molecular Biology of the Cell. 19:1739-1752
Cell polarization in response to external cues is critical to many eukaryotic cells. During pheromone-induced mating in Saccharomyces cerevisiae, the mitogen-activated protein kinase (MAPK) Fus3 induces polarization of the actin cytoskeleton toward a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfbd9614f11b6682976df3870376598
https://doi.org/10.1091/mbc.e07-08-0757
https://doi.org/10.1091/mbc.e07-08-0757
Autor:
Elaine A. Elion
All eukaryotic cells utilize multiple mitogen-activated protein (MAP) kinase cascades to respond to a wide variety of external and internal stimuli to regulate proliferation, differentiation, morphogenesis, survival, stress, and development; with muc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fd91ac3fde9bb410db9758f234cf78
https://doi.org/10.1016/b978-0-12-801238-3.98742-7
https://doi.org/10.1016/b978-0-12-801238-3.98742-7
Autor:
Maosong Qi, Elaine A. Elion
Publikováno v:
Journal of Cell Science. 118:3569-3572
Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate numerous proteins, including transcription factors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaecf26348531ceeab037e7d97b488c
https://doi.org/10.1242/jcs.02470
https://doi.org/10.1242/jcs.02470
Publikováno v:
Journal of Biological Chemistry. 280:13084-13096
The Saccharomyces cerevisiae guanine nucleotide exchange factor Cdc24 regulates polarized growth by binding to Cdc42, a Rho-type GTPase that has many effectors, including Ste20 kinase, which activates multiple MAPK cascades. Here, we show that Cdc24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f4f875cf01186295a97c5cd2be8c65
https://doi.org/10.1074/jbc.m410461200
https://doi.org/10.1074/jbc.m410461200
Publikováno v:
Journal of Biological Chemistry. 279:47391-47401
Scaffold proteins play pivotal roles during signal transduction. In Saccharomyces cerevisiae, the Ste5p scaffold protein is required for activation of the mating MAPK cascade in response to mating pheromone and assembles a G protein-MAPK cascade comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c241bc8bcfa0ee09184b4376223e30c
https://doi.org/10.1074/jbc.m405681200
https://doi.org/10.1074/jbc.m405681200
Publikováno v:
The EMBO Journal. 23:2564-2576
Pathway specificity is poorly understood for mitogen-activated protein kinase (MAPK) cascades that control different outputs in response to different stimuli. In yeast, it is not known how the same MAPK cascade activates Kss1 MAPK to promote invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3925158c2b2028589b4551cee0b8c65f
https://doi.org/10.1038/sj.emboj.7600250
https://doi.org/10.1038/sj.emboj.7600250
Autor:
Elaine A. Elion, Vera Cherkasova
Publikováno v:
Current Genetics. 40:13-26
In Saccharomyces cerevisiae, mating pheromones induce G1 arrest through the activation of two MAP kinases, Fus3 and Kss1. Here we report the isolation of three mutants, far4, far5, and far6, that have the novel phenotype of regulating both the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e569bc02e43e943d420781c64526d04
https://doi.org/10.1007/s002940100217
https://doi.org/10.1007/s002940100217