Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Elaine, Sanders-Bush"'
Autor:
Uade B Olaghere Da Silva, Michael V Morabito, Clinton E Canal, David C Airey, Ronald B Emeson, Elaine Sanders-Bush
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Transcripts encoding 5-HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT2C-VGV, exhibits blunted G-protein coupling and reduced constitutive ac
Externí odkaz:
https://doaj.org/article/ba24d819bba5466da6eb2677ee25a476
Autor:
Elaine Sanders-Bush, David C. Airey, Ana Carneiro, Jing Wang, Lu Lu, Ran Ye, Bing Zhang, Randy D. Blakely, Robert W. Williams
Publikováno v:
Genes, Brain and Behavior. 13:247-260
The biogenic amine serotonin (5-HT, 5-hydroxytryptamine) exerts powerful, modulatory control over multiple physiological functions in the brain and periphery, ranging from mood and appetite to vasoconstriction and gastrointestinal motility. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e78717a7ee249252897330a88e11bf
https://doi.org/10.1111/gbb.12092
https://doi.org/10.1111/gbb.12092
Autor:
Ana Carneiro, Elaine Sanders-Bush, Charisma R. Shah, W. Anthony Owens, Brent J. Thompson, Hideki Iwamoto, Ran Ye, Jennifer E. Sauer, Padmanabhan Mannangatti, Douglas G. McMahon, James S. Sutcliffe, Jordan Cohen, Lynette C. Daws, Randy D. Blakely, Jacqueline N. Crawley, Christopher L. Muller, Travis M. Kerr, Sammanda Ramamoorthy, Jeremy Veenstra-VanderWeele, Tammy Jessen
Publikováno v:
Proceedings of the National Academy of Sciences. 109:5469-5474
Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter (SERT) gene ( SLC6A4 ) has been associated with whole blood 5-HT levels an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0607ccebeff97d30fe39578b806dd5
https://doi.org/10.1073/pnas.1112345109
https://doi.org/10.1073/pnas.1112345109
Publikováno v:
Neuroscience
Previous human postmortem brain tissue research has implicated abnormalities of 5-HT receptor availability in depression and suicide. Although altered abundance of 5-HT 1A, 5-HT 2A, and 5-HT 2C receptors (5-HT(1A), 5-HT(2A), and 5-HT(2C)) has been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7cd5d9f14f73f4a83d99ca079f8d35
https://doi.org/10.1016/j.neuroscience.2008.11.036
https://doi.org/10.1016/j.neuroscience.2008.11.036
Autor:
David C. Airey, Elaine Sanders-Bush
Publikováno v:
Molecular Interventions. 8:200-203
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acf12ba2f8f827110c4156a39f916d5
https://doi.org/10.1124/mi.8.5.1
https://doi.org/10.1124/mi.8.5.1
Publikováno v:
Neuropharmacology. 52:1671-1677
Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that G(q)-coupled 5-HT(2A) receptors are likely targets for the initiation of events leading to the ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9f48a63300e54dc26cbabb5d3c42a9
https://doi.org/10.1016/j.neuropharm.2007.03.013
https://doi.org/10.1016/j.neuropharm.2007.03.013
Autor:
Douglas E. Vaughan, Elaine Sanders-Bush, Nancy J. Brown, Corrie A. Painter, James A.S. Muldowney
Publikováno v:
Thrombosis and Haemostasis. 97:263-271
SummaryThe acute physiologic release of tissue-type plasminogen activator (t-PA) from the endothelium is critical for vascular homeostasis. This process is prostacyclin- and nitric oxide (NO)-independent in humans. It has been suggested that calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c88433a1ab06a1fa211d66c014f1e7e7
https://doi.org/10.1160/th05-02-0092
https://doi.org/10.1160/th05-02-0092
Autor:
Elaine Sanders-Bush, Ian D. Tomlinson, Sandra J. Rosenthal, David M. Hercules, Anthony P. Gies, Paul J. Gresch, Joel Dillard, Rebecca L. Orndorff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6262-6266
Biologically active small molecule derivatives that can be conjugated to quantum dots have the promise of revolutionizing fluorescent imaging in biology. In order to achieve this several technical hurdles have to be surmounted, one of which is non-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01931a7b6e6df6af380c63dc3cd9658
https://doi.org/10.1016/j.bmcl.2006.09.031
https://doi.org/10.1016/j.bmcl.2006.09.031
Autor:
Elizabeth A. Hackler, Elaine Sanders-Bush, Paul J. Gresch, Saikat Sengupta, John C. Gore, Greg H. Turner, Ariel Y. Deutch, Malcolm J. Avison
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:1023-1029
Activation of 5-hydroxytryptamine2C (5-HT(2C)) receptors by the 5-HT(2) receptor agonist m-chlorophenylpiperazine (m-CPP) elicits anxiety in humans and anxiety-like behavior in animals. We compared the effects of m-CPP with the anxiogenic GABA(A) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc02c700a496a8096ea69770786cff10
https://doi.org/10.1124/jpet.106.113357
https://doi.org/10.1124/jpet.106.113357
Autor:
David C. Airey, Monsheel S. Sodhi, Caitlin C. Shannon, Elaine Sanders-Bush, Elizabeth A. Hackler
Publikováno v:
Neuroscience Research. 55:96-104
Post-transcriptional RNA editing of the G-protein coupled 5-hydroxytryptamine-2C (5-HT 2C ) receptor predicts an array of 24 receptor isoforms, some of which are characterized by reduced constitutive activity and potency to initiate intracellular sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c6db43f49b8257bd16e7d203afc81c
https://doi.org/10.1016/j.neures.2006.02.005
https://doi.org/10.1016/j.neures.2006.02.005