Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Autor: Sara Larivière, Jessica Royer, Raúl Rodríguez-Cruces, Casey Paquola, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Clarissa L. Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Martin Domin, Felix von Podewills, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Terence J. O’Brien, Benjamin Sinclair, Lucy Vivash, Patricia M. Desmond, Elaine Lui, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Gavin P. Winston, Aoife Griffin, Aditi Singh, Vijay K. Tiwari, Barbara A. K. Kreilkamp, Matteo Lenge, Renzo Guerrini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N. Hatton, Sjoerd B. Vos, Lorenzo Caciagli, John S. Duncan, Christopher D. Whelan, Paul M. Thompson, Sanjay M. Sisodiya, Andrea Bernasconi, Angelo Labate, Carrie R. McDonald, Neda Bernasconi, Boris C. Bernhardt

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Epilepsy is a brain network disorder with associated genetic risk factors. Here, the authors show that spatial patterns of transcriptomic vulnerability co-vary with structural brain network alterations in focal and generalized epilepsy.

Externí odkaz: https://doaj.org/article/42a2adc39a114a5faf720bcffa41fabd

Effect of porosity of a functionally-graded scaffold for the treatment of corticosteroid-associated osteonecrosis of the femoral head in rabbits

Autor: Masahiro Maruyama, Chi-Chun Pan, Seyedsina Moeinzadeh, Hunter W. Storaci, Roberto Alfonso Guzman, Elaine Lui, Masaya Ueno, Takeshi Utsunomiya, Ning Zhang, Claire Rhee, Zhenyu Yao, Michiaki Takagi, Stuart B. Goodman, Yunzhi Peter Yang

Publikováno v: Journal of Orthopaedic Translation, Vol 28, Iss , Pp 90-99 (2021)

Background/Objective: Core decompression (CD) with scaffold and cell-based therapies is a promising strategy for providing both mechanical support and regeneration of the osteonecrotic area for early stage osteonecrosis of the femoral head (ONFH). We

Externí odkaz: https://doaj.org/article/25ad4d0f3ace44fc9acf86b1fb945e7c

Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus

Autor: Yunzhi Peter Yang, Kevin M. Labus, Benjamin C. Gadomski, Arnaud Bruyas, Jeremiah Easley, Brad Nelson, Ross H. Palmer, Kirk McGilvray, Daniel Regan, Christian M. Puttlitz, Alexander Stahl, Elaine Lui, Jiannan Li, Seyedsina Moeinzadeh, Sungwoo Kim, William Maloney, Michael J. Gardner

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic prote

Externí odkaz: https://doaj.org/article/041118049a384bd1920ca166cdd8d42f

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study

Autor: Ezequiel Gleichgerrcht, Brent C. Munsell, Saud Alhusaini, Marina K.M. Alvim, Núria Bargalló, Benjamin Bender, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Karen Blackmon, Maria Eugenia Caligiuri, Fernando Cendes, Luis Concha, Patricia M. Desmond, Orrin Devinsky, Colin P. Doherty, Martin Domin, John S. Duncan, Niels K. Focke, Antonio Gambardella, Bo Gong, Renzo Guerrini, Sean N. Hatton, Reetta Kälviäinen, Simon S. Keller, Peter Kochunov, Raviteja Kotikalapudi, Barbara A.K. Kreilkamp, Angelo Labate, Soenke Langner, Sara Larivière, Matteo Lenge, Elaine Lui, Pascal Martin, Mario Mascalchi, Stefano Meletti, Terence J. O'Brien, Heath R. Pardoe, Jose C. Pariente, Jun Xian Rao, Mark P. Richardson, Raúl Rodríguez-Cruces, Theodor Rüber, Ben Sinclair, Hamid Soltanian-Zadeh, Dan J. Stein, Pasquale Striano, Peter N. Taylor, Rhys H. Thomas, Anna Elisabetta Vaudano, Lucy Vivash, Felix von Podewills, Sjoerd B. Vos, Bernd Weber, Yi Yao, Clarissa Lin Yasuda, Junsong Zhang, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Leonardo Bonilha, Andre Altmann, Chantal Depondt, Marian Galovic, Sophia I. Thomopoulos, Roland Wiest

Publikováno v: NeuroImage: Clinical, Vol 31, Iss , Pp 102765- (2021)

Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for pat

Externí odkaz: https://doaj.org/article/04e5634905854974bc8546298c41b38c

Resting-state functional connectivity and quantitation of glutamate and GABA of the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy individuals.

Autor: Ofer M Gonen, Bradford A Moffat, Patrick Kwan, Terence J O'Brien, Patricia M Desmond, Elaine Lui

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244491 (2020)

The default mode network (DMN) is the main large-scale network of the resting brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA (γ-amino butyric acid) are the main excitatory and inhibitory neurotransmitters in the CNS,

Externí odkaz: https://doaj.org/article/585b3ef8c4c44db29559e72dab56b1dc