Zobrazeno 1 - 10
of 732
pro vyhledávání: '"Elaine, Holmes"'
Publikováno v:
Nutrients, Vol 16, Iss 17, p 2923 (2024)
The evidence on the impact of fruits and vegetable types on cardiovascular risk factors remains limited. Specifically, the utilisation of biomarkers to objectively measure dietary compliance and metabolic responses is emerging. This protocol and base
Externí odkaz:
https://doaj.org/article/98f0d7b1f786484499fe4e1cc560de3e
Autor:
Liam H. Walsh, Aaron M. Walsh, Isabel Garcia-Perez, Fiona Crispie, Adele Costabile, Richard Ellis, Jim Finlayson, Laura A. Finnegan, Marcus J. Claesson, Elaine Holmes, Paul D. Cotter
Publikováno v:
npj Science of Food, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract It has been established that the human gut microbiota is central to health, and, consequently, there has been a growing desire to positively modulate its composition and/or function through, for example, the use of fermented foods, prebiotic
Externí odkaz:
https://doaj.org/article/501e5ddda47a4c718110d03c357abe9f
Autor:
Charlotte E. Rowley, Samantha Lodge, Siobhon Egan, Catherine Itsiopoulos, Claus T. Christophersen, Desiree Silva, Elizabeth Kicic-Starcevich, Therese A. O’Sullivan, Julien Wist, Jeremy Nicholson, Gary Frost, Elaine Holmes, Nina D’Vaz
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
RationaleEvidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and uri
Externí odkaz:
https://doaj.org/article/ff03e983f9fb451ea3688a1d19d37b44
Autor:
Laura Martinez-Gili, Alexandros Pechlivanis, Julie A.K. McDonald, Sofina Begum, Jonathan Badrock, Jessica K. Dyson, Rebecca Jones, Gideon Hirschfield, Stephen D. Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor-Robinson, Mary M.E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk of progressing to cirrhosis, but the underlying mechanis
Externí odkaz:
https://doaj.org/article/96120242cd9d46b48c536c4461b39cb1
Autor:
Peter Yuli Xing, Ruchi Agrawal, Anusha Jayaraman, Katherine Ann Martin, George Wei Zhang, Ee Ling Ngu, Llanto Elma Faylon, Staffan Kjelleberg, Scott A. Rice, Yulan Wang, Adesola T. Bello, Elaine Holmes, Jeremy K. Nicholson, Luke Whiley, Sven Pettersson
Publikováno v:
Microorganisms, Vol 12, Iss 4, p 719 (2024)
Gut microbes supporting body growth are known but the mechanisms are less well documented. Using the microbial tryptophan metabolite indole, known to regulate prokaryotic cell division and metabolic stress conditions, we mono-colonized germ-free (GF)
Externí odkaz:
https://doaj.org/article/02a744344aaf4d7ea6ceadd37893427f
Autor:
Nicholas C. Penney, Derek K. T. Yeung, Isabel Garcia-Perez, Joram M. Posma, Aleksandra Kopytek, Bethany Garratt, Hutan Ashrafian, Gary Frost, Julian R. Marchesi, Sanjay Purkayastha, Lesley Hoyles, Ara Darzi, Elaine Holmes
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)
Penney et al. conduct microbial and metabolic profiling in people with obesity, with or without type 2 diabetes, undergoing two types of bariatric surgery. Integrative analysis identifies multi-omic signatures associated with response to surgery, bod
Externí odkaz:
https://doaj.org/article/ae66a20ad45b4ba39165761a0a037a62
Autor:
Sofina Begum, Samantha Lodge, Drew Hall, Blair Z. Johnson, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Mark W. Fear, Elaine Holmes, Fiona M. Wood, Jeremy K. Nicholson
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
IntroductionBurn injury in children causes prolonged systemic effects on physiology and metabolism leading to increased morbidity and mortality, yet much remains undefined regarding the metabolic trajectory towards specific health outcomes.MethodsA m
Externí odkaz:
https://doaj.org/article/4f97c39a6f6c4832aeb66d011d4f13e4
Autor:
Sofina Begum, Blair Z. Johnson, Aude-Claire Morillon, Rongchang Yang, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Leila Cuttle, Andrew J. A. Holland, Jeremy K. Nicholson, Fiona M. Wood, Mark W. Fear, Elaine Holmes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In
Externí odkaz:
https://doaj.org/article/bd738ef484744b0d99df495bd98504fa
Autor:
Iain Robert Louis Kean, Joseph Wagner, Anisha Wijeyesekera, Marcus De Goffau, Sarah Thurston, John A. Clark, Deborah K. White, Jenna Ridout, Shruti Agrawal, Riaz Kayani, Roddy O’Donnell, Padmanabhan Ramnarayan, Mark J. Peters, Nigel Klein, Elaine Holmes, Julian Parkhill, Stephen Baker, Nazima Pathan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Broad-spectrum antimicrobial use during the treatment of critical illness influences gastrointestinal fermentation endpoints, host immune response and metabolic activity including the conversion of primary to secondary bile acids. We previou
Externí odkaz:
https://doaj.org/article/f50ca951fceb41579f359fd10dab04c7
Autor:
David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, Simon D. Taylor-Robinson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy. It has been proposed that HCV genotype
Externí odkaz:
https://doaj.org/article/784b398a1e0e4b7cb22ed7e9bb1f9fb4