Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elaina N Maginn"'
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Platinum-based chemotherapy is the cornerstone of ovarian cancer treatment, and its efficacy is dependent on the generation of DNA damage, with subsequent induction of apoptosis. Inappropriate or aberrant activation of the DNA damage response network
Externí odkaz:
https://doaj.org/article/254619414f0748d4986d6385ca1a55ac
Autor:
Mark Lawler, Daniela M. Zisterer, D. Clive Williams, Elisabeth Vandenberghe, Mark A. Catherwood, Giuseppe Campiani, Stefania Butini, Paul V. Browne, Amjad Hayat, Siobhan McGuckin, Lisa M. Greene, Elaina N. Maginn, Anthony M. McElligott
Supplementary Figure Legend from The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ac8e5beb89534efc364ccf43606715
https://doi.org/10.1158/0008-5472.22379894.v1
https://doi.org/10.1158/0008-5472.22379894.v1
Autor:
Mark Lawler, Daniela M. Zisterer, D. Clive Williams, Elisabeth Vandenberghe, Mark A. Catherwood, Giuseppe Campiani, Stefania Butini, Paul V. Browne, Amjad Hayat, Siobhan McGuckin, Lisa M. Greene, Elaina N. Maginn, Anthony M. McElligott
Pyrrolo-1,5-benzoxazepine-15 (PBOX-15) is a novel microtubule depolymerization agent that induces cell cycle arrest and subsequent apoptosis in a number of cancer cell lines. Chronic lymphocytic leukemia (CLL) is characterized by clonal expansion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc490614fe6ca8eefef8c52349c98a22
https://doi.org/10.1158/0008-5472.c.6499382.v1
https://doi.org/10.1158/0008-5472.c.6499382.v1
Autor:
Mark Lawler, Daniela M. Zisterer, D. Clive Williams, Elisabeth Vandenberghe, Mark A. Catherwood, Giuseppe Campiani, Stefania Butini, Paul V. Browne, Amjad Hayat, Siobhan McGuckin, Lisa M. Greene, Elaina N. Maginn, Anthony M. McElligott
Supplementary Figure 1 from The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246cf98ac4163ac7a53578882209a326
https://doi.org/10.1158/0008-5472.22379897
https://doi.org/10.1158/0008-5472.22379897
Publikováno v:
Cancer Biology & Therapy
Pancreatic ductal adenocarcinoma (PDAC) progression and chemotherapy insensitivity have been associated with aberrant PI3K/mTOR/MEK signalling. However, cell death responses activated by inhibitors of these pathways can differ – contextually varyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2b8195fd7a09e8d83f705ee579e4d7
https://pubmed.ncbi.nlm.nih.gov/30261145
https://pubmed.ncbi.nlm.nih.gov/30261145
Publikováno v:
Cancer Research. 78:2876-2876
Dysregulation of DNA damage response and repair (DDR) is common in pancreatic and other cancers, and impairs their sensitivity to DNA damaging agents. Targeting DDR mediators is therefore an attractive strategy to improve response to DNA damaging age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef31be1eb3d9906b883b3613c69d5f6b
https://doi.org/10.1158/1538-7445.am2018-2876
https://doi.org/10.1158/1538-7445.am2018-2876
Autor:
Paul Browne, Mark Catherwood, Lisa M. Greene, Mark Lawler, D. Clive Williams, Elaina N. Maginn, Amjad Hayat, Elisabeth Vandenberghe, Stefania Butini, Daniela M. Zisterer, Anthony M. McElligott, Siobhan McGuckin, Giuseppe Campiani
Publikováno v:
Cancer Research. 69:8366-8375
Pyrrolo-1,5-benzoxazepine-15 (PBOX-15) is a novel microtubule depolymerization agent that induces cell cycle arrest and subsequent apoptosis in a number of cancer cell lines. Chronic lymphocytic leukemia (CLL) is characterized by clonal expansion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b17867842d8ef1d793f867fa622db2
https://doi.org/10.1158/0008-5472.can-09-0131
https://doi.org/10.1158/0008-5472.can-09-0131
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 5 (2015)
Frontiers in Oncology, Vol 5 (2015)
Platinum-based chemotherapy is the cornerstone of ovarian cancer treatment, and its efficacy is dependent on the generation of DNA damage, with subsequent induction of apoptosis. Inappropriate or aberrant activation of the DNA damage response network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c915adadfa58afdc5fa96c3e8cb50aef
https://doi.org/10.3389/fonc.2015.00240
https://doi.org/10.3389/fonc.2015.00240
Publikováno v:
Biochimica et biophysica acta. 1846(1)
Pancreatic ductal adenocarcinoma (PDAC) remains one of the poorest prognosis neoplasms. It is typified by high levels of genomic aberrations and copy-number variation, intra-tumoural heterogeneity and resistance to conventional chemotherapy. Improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a415f60fab69285528818312e662221
https://pubmed.ncbi.nlm.nih.gov/24727386
https://pubmed.ncbi.nlm.nih.gov/24727386
Autor:
Mark Lawler, J Ryan, Paul Browne, Daniela M. Zisterer, D. Clive Williams, Navin Kumar Verma, Joanne Lysaght, Anthony M. McElligott, Giuseppe Campiani, Elaina N. Maginn
Although recent decades have seen an improved cure rate for newly diagnosed paediatric acute lymphoplastic leukaemia (ALL), the treatment options for adult ALL, T-cell ALL (T-ALL) and relapsed disease remain poor. We have developed a novel series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ff1c014e3586696b188537dc2ebee9
http://hdl.handle.net/11365/48708
http://hdl.handle.net/11365/48708