Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elaina M. Melton"'
Autor:
Maximillian A. Rogers, Catherine C. Y. Chang, Robert A. Maue, Elaina M. Melton, Andrew A. Peden, William S. Garver, Junghoon Lee, Peter Schroen, Mitchell Huang, Ta-Yuan Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Niemann-Pick type C disease (NPCD) is an incurable genetic neurological disorder. Cells with NPC mutations fail to export cholesterol from endosomal organelle to multiple other organelles. ACAT1 is an enzyme that converts cholesterol to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a817a781ec7473dfbd6a89ca2b7e952a
https://doi.org/10.1073/pnas.2201646119
https://doi.org/10.1073/pnas.2201646119
Autor:
Li-Hao Huang, Bo-Liang Li, Paul Sohn, Bao-Liang Song, Jalen Benson, Catherine C.Y. Chang, Haibo Li, Ta-Yuan Chang, Elaina M. Melton
Publikováno v:
Journal of Biological Chemistry. 294:15836-15849
Cholesterol esters are a key ingredient of foamy cells in atherosclerotic lesions; their formation is catalyzed by two enzymes: acyl-CoA:cholesterol acyltransferases (ACATs; also called sterol O-acyltransferases, or SOATs) ACAT1 and ACAT2. ACAT1 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbe2a58c43223d18275b5465bbf56089
https://doi.org/10.1074/jbc.ra119.010564
https://doi.org/10.1074/jbc.ra119.010564
Autor:
Mitchell M. Huang, Peter W. Schroen, Ta-Yuan Chang, Andrew A. Peden, Elaina M. Melton, William S. Garver, Robert A. Maue, Catherine C.Y. Chang, Maximillian A. Rogers
Niemann-Pick type C (NPC) is a neurological disorder with no cure. NPC proteins deliver cholesterol from endosomes to other compartments including trans-Golgi network (TGN) and endoplasmic reticulum (ER). Acyl-coenzyme A:cholesterol acyltransferase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9618278c3b5c0edc6606dae18ff3d85d
https://doi.org/10.1101/2020.08.07.241471
https://doi.org/10.1101/2020.08.07.241471
Autor:
Frances L Jourd'heuil, Anthony M Lowery, Elaina M Melton, Sanie Mnaimneh, Nathan S Bryan, Bernadette O Fernandez, Joo-Ho Park, Chung-Eun Ha, Nadhipuram V Bhagavan, Martin Feelisch, David Jourd'heuil
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14400 (2010)
S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins--is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport. Recent studies would also suggest the formation of N-nitros
Externí odkaz:
https://doaj.org/article/9e401a980b4a4d5dbb9b4080e9c368e1
Autor:
Elaina M, Melton, Haibo, Li, Jalen, Benson, Paul, Sohn, Li-Hao, Huang, Bao-Liang, Song, Bo-Liang, Li, Catherine C Y, Chang, Ta-Yuan, Chang
Publikováno v:
J Biol Chem
Cholesterol esters are a key ingredient of foamy cells in atherosclerotic lesions; their formation is catalyzed by two enzymes: acyl-CoA:cholesterol acyltransferases (ACATs; also called sterol O-acyltransferases, or SOATs) ACAT1 and ACAT2. ACAT1 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::161015220cf4161aebd2a533bda69e69
https://pubmed.ncbi.nlm.nih.gov/31495784
https://pubmed.ncbi.nlm.nih.gov/31495784
Autor:
Elaina M. Melton, Steven Fiering, Paul Sohn, Catherine C.Y. Chang, Maximillian A. Rogers, Ta-Yuan Chang, Mary Jo Mulligan-Kehoe, Haibo Li, William F. Hickey, Li-Hao Huang
Publikováno v:
Journal of Biological Chemistry. 291:6232-6244
Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. However, in mouse models for atherosclerosis, global Acat1 knockout (Acat1(-/-)) did not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924621f658bf55ae047c4506273a2d97
https://doi.org/10.1074/jbc.m116.713818
https://doi.org/10.1074/jbc.m116.713818
Autor:
Catherine C.Y. Chang, Jason K. Kim, DaeYoung Jung, Ching-Yi Tsai, Edward J. Usherwood, Tian Ma, Elaina M. Melton, Hiroyuki Sano, Randall H. Friedline, Ta-Yuan Chang, Paul Sohn, Li-Hao Huang, Hyekyung Ha, Haibo Li
Macrophages are phagocytes that play important roles in health and diseases. Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Unlike global Acat1 knockout (KO), my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97cf81fa0a10a84f748cc19c98138ee
https://europepmc.org/articles/PMC6171008/
https://europepmc.org/articles/PMC6171008/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1771:1246-1253
Long chain acyl-CoA synthetase (ACSL; fatty acid CoA ligase: AMP forming; EC 6.2.1.3) catalyzes the formation of acyl-CoA through a process, which requires fatty acid, ATP and coenzymeA as substrates. In the yeast Saccharomyces cerevisiae the princip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4cefb791872c2ecf2e5ddd107e1fa7
https://doi.org/10.1016/j.bbalip.2007.05.009
https://doi.org/10.1016/j.bbalip.2007.05.009
In mammals, the fatty acid transport proteins (FATP1 through FATP6) are members of a highly conserved family of proteins, which function in fatty acid transport proceeding through vectorial acylation and in the activation of very long chain fatty aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc96faa7871e974925f140fef6136c
https://europepmc.org/articles/PMC4665974/
https://europepmc.org/articles/PMC4665974/
Publikováno v:
The Journal of biological chemistry. 286(35)
The trafficking of fatty acids across the membrane and into downstream metabolic pathways requires their activation to CoA thioesters. Members of the fatty acid transport protein/very long chain acyl-CoA synthetase (FATP/Acsvl) family are emerging as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90191a97aaf79332e580baef40ab5dd2
https://pubmed.ncbi.nlm.nih.gov/21768100
https://pubmed.ncbi.nlm.nih.gov/21768100