Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Elaina M. Kenyon"'
Publikováno v:
Toxicol In Vitro
Metabolic rate parameters estimation using in vitro data is necessary due to numbers of chemicals for which data are needed, trend towards minimizing laboratory animal use, and limited opportunity to collect data in human subjects. We evaluated how w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefca253c8768d56daa2aee3b989bd6e
https://europepmc.org/articles/PMC8607508/
https://europepmc.org/articles/PMC8607508/
Autor:
Jane Ellen Simmons, Natalia Ryan, Yusupha M Sey, Elaina M. Kenyon, Judith E. Schmid, Susan D. Hester, Leah C. Wehmas, Brian N. Chorley, Michael F. Hughes, Alan H. Tennant, Charles E. Wood, Barbara Jane George, J. Christopher Corton, John P. Rooney
Publikováno v:
Toxicology. 465:153046
Short-term biomarkers of toxicity have an increasingly important role in the screening and prioritization of new chemicals. In this study, we examined early indicators of liver toxicity for three reference organophosphate (OP) chemicals, which are am
Publikováno v:
Toxicology in Vitro. 75:105045
Autor:
Elaina M. Kenyon
Publikováno v:
Toxicology
Arsenic (As) poses unique challenges in PBTK model development and risk analysis applications. Arsenic metabolism is complex, adequate information to attribute specific metabolites to particular adverse effects in humans is sparse, and measurement of
Autor:
Brian N. Chorley, Jane Ellen Simmons, Alan H. Tennant, Judith E. Schmid, Charles E. Wood, Arun R. Pandiri, Susan D. Hester, J. Christopher Corton, Charlene A. McQueen, Denise K. MacMillan, John P. Rooney, Natalia Ryan, Michael F. Hughes, Barbara Jane George, Elaina M. Kenyon, Yusupha M. Sey
Publikováno v:
Toxicological Sciences. 160:15-29
Current strategies for predicting carcinogenic mode of action for nongenotoxic chemicals are based on identification of early key events in toxicity pathways. The goal of this study was to evaluate short-term key event indicators resulting from expos
Publikováno v:
Toxicology Mechanisms and Methods. 26:620-626
A rate for hepatic metabolism (Vmax) determined in vitro must be scaled for in vivo use in a physiologically based pharmacokinetic (PBPK) model. This requires the use of scaling factors such as mg of microsomal protein per gram of liver (MPPGL) and l
Publikováno v:
Journal of Applied Toxicology. 36:1095-1111
As a result of its presence in water as a volatile disinfection byproduct, bromodichloromethane (BDCM), which is mutagenic, poses a potential health risk from exposure via oral, dermal and inhalation routes. We developed a refined human physiological
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 167(2)
Biotransformation rates extrapolated from in vitro data are used increasingly in human physiologically based pharmacokinetic (PBPK) models. This practice requires use of scaling factors, including microsomal content (mg of microsomal protein/g liver,
Autor:
Beth Padnos, Alan H. Tennant, Charlene A. McQueen, Charles E. Wood, Jane Ellen Simmons, Michael F. Hughes, April D. Lake, David G. Ross, Yusupha M. Sey, J. Christopher Corton, Barbara Jane George, Susan D. Hester, Brian N. Chorley, Elaina M. Kenyon, Tanya Moore, Gleta Carswell, Virunya S. Bhat, Judith E. Schmid
Publikováno v:
Toxicological Sciences. 149:312-325
Current strategies for predicting adverse health outcomes of environmental chemicals are centered on early key events in toxicity pathways. However, quantitative relationships between early molecular changes in a given pathway and later health effect
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 42:591-609
Any statistical model should be identifiable in order for estimates and tests using it to be meaningful. We consider statistical analysis of physiologically-based pharmacokinetic (PBPK) models in which parameters cannot be estimated precisely from av