Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7

Autor: Veronika Bandara, Jade Foeng, Batjargal Gundsambuu, Todd S. Norton, Silvana Napoli, Dylan J. McPeake, Timona S. Tyllis, Elaheh Rohani-Rad, Caitlin Abbott, Stuart J. Mills, Lih Y. Tan, Emma J. Thompson, Vasiliki M. Willet, Victoria J. Nikitaras, Jieren Zheng, Iain Comerford, Adam Johnson, Justin Coombs, Martin K. Oehler, Carmela Ricciardelli, Allison J. Cowin, Claudine S. Bonder, Michael Jensen, Timothy J. Sadlon, Shaun R. McColl, Simon C. Barry

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple sol

Externí odkaz: https://doaj.org/article/a5287b5698b04be1aa66caa9922e1384

Pre-clinical validation of a novel pan-cancer CAR-T cell immunotherapy against nfP2X7

Autor: Claudine S. Bonder, Timona S. Tyllis, Simon Barry, Shaun R. McColl, Silvana Napoli, Victoria Nikitaras, Jade Foeng, Michael C. Jensen, Veronika Bandara, Justin Taylor Coombs, Vasiliki Willet, Timothy John Sadlon, Lih Tan, Caitlin Abbott, Elaheh Rohani Rad, Allison J. Cowin, Batjargal Gundsambuu, Stuart J. Mills, Todd Norton, Carmela Ricciardelli, Adam Johnson, Martin K. Oehler, Dylan McPeake

Chimeric antigen receptor (CAR)-T immunotherapy is a novel treatment that genetically modifies the patient’s own T cells to target and kill malignant cells. CAR-T cells demonstrated robust clinical activity against certain B-cell malignancies. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68ae0739107f30e52947cdac353f8ca4
https://doi.org/10.21203/rs.3.rs-1073214/v1

Biodegradable polyester thin films and coatings in the line of fire: the time of polyhydroxyalkanoate (PHA)?

Autor: Thibault Parpaite, Henri Vahabi, Elaheh Rohani Rad, Mohammad Reza Saeb, Valérie Langlois

Publikováno v: Progress in Organic Coatings
Progress in Organic Coatings, Elsevier, 2019, 133, pp.85-89. ⟨10.1016/j.porgcoat.2019.04.044⟩
Progress in Organic Coatings, 2019, 133, pp.85-89. ⟨10.1016/j.porgcoat.2019.04.044⟩

From sustainability standpoint, bio-based resins are of crucial importance nowadays rather than fossil-based resins, but the former suffers from low flame retardancy. Bio-based thin films and coatings are in their early stage of development; hence, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1973e099bb59f9fc13504a9a5d3fd92
https://doi.org/10.1016/j.porgcoat.2019.04.044

Abstract 5505: ADAM10-targeting CAR-T cells inhibit colon cancer cell growth in vivo

Autor: Elaheh Rohani Rad, Jade Foeng, Dylan McPeak, Timona Tyllis, Caitlin Abbott, Veronika bandara, Silvana Napoli, Batjargal gundsambuu, Simon Barry, Timothy Sadlon, shaun McColl

Publikováno v: Cancer Research. 82:5505-5505

Chimeric antigen receptor (CAR) T cell therapy has demonstrated a high degree of efficacy in patients with hematological malignancies such as acute lymphatic leukemia. However, its efficacy in solid tumors remains to be demonstrated. There are a numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65463bf7047076de2a2dc80e75fc6150
https://doi.org/10.1158/1538-7445.am2022-5505