Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Elah Pick"'
Autor:
Swarnab Sengupta, Elah Pick
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 734 (2023)
In this review, we present a comprehensive list of the ubiquitin-like modifiers (Ubls) of Saccharomyces cerevisiae, a common model organism used to study fundamental cellular processes that are conserved in complex multicellular organisms, such as hu
Externí odkaz:
https://doaj.org/article/0fd8d850398f4b179a381008973a7af2
Autor:
Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 129-138 (2020)
The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medi
Externí odkaz:
https://doaj.org/article/40e1c1c58ff541c6906128d70d7d2c1e
Autor:
Elah Pick
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101765- (2020)
Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid defense me
Externí odkaz:
https://doaj.org/article/be46e8f1b39b420fab9c15ca4413c83f
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 497 (2021)
The COP9 signalosome (CSN) is a highly conserved eukaryotic multi-subunit enzyme, regulating cullin RING ligase activities and accordingly, substrate ubiquitination and degradation. We showed that the CSN complex of Saccharomyces cerevisiae that is d
Externí odkaz:
https://doaj.org/article/6b3844ad7a3146a58175a81c485dbb6c
Publikováno v:
Biomolecules, Vol 4, Iss 4, Pp 897-930 (2014)
The ability of viruses to subvert host pathways is central in disease pathogenesis. Over the past decade, a critical role for the Ubiquitin Proteasome System (UPS) in counteracting host immune factors during viral infection has emerged. This countera
Externí odkaz:
https://doaj.org/article/af9e61e74e844a9ca1e2d136a04bc2ef
Autor:
Laylan Bramasole, Abhishek Sinha, Dana Harshuk, Angela Cirigliano, Gurevich Sylvia, Zanlin Yu, Rinat Lift Carmeli, Michael H. Glickman, Teresa Rinaldi, Elah Pick
Publikováno v:
Biomolecules, Vol 9, Iss 9, p 449 (2019)
The class of Cullin−RING E3 ligases (CRLs) selectively ubiquitinate a large portion of proteins targeted for proteolysis by the 26S proteasome. Before degradation, ubiquitin molecules are removed from their conjugated proteins by deubiquitinating e
Externí odkaz:
https://doaj.org/article/fb2309b1301d4e8786277a08077d00d6
Autor:
Zanlin Yu, Nurit Livnat‑Levanon, Oded Kleifeld, Wissam Mansour, Mark A. Nakasone, Carlos A. Castaneda, Emma K. Dixon, David Fushman, Noa Reis, Elah Pick, Michael H. Glickman
Publikováno v:
Bioscience Reports, Vol 35, Iss 3, p e00194 (2015)
26S proteasome, a major regulatory protease in eukaryotes, consists of a 20S proteolytic core particle (CP) capped by a 19S regulatory particle (RP). The 19S RP is divisible into base and lid sub-complexes. Even within the lid, subunits have been dem
Externí odkaz:
https://doaj.org/article/0618ac0b392b4f939b99383df1106c7d
Autor:
Elah Pick, Amnon Golan, Jacob Z Zimbler, Liquan Guo, Yehonatan Sharaby, Tomohiko Tsuge, Kay Hofmann, Ning Wei
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43980 (2012)
The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through modulating the cullin ubiquitin E3 ligases in the ubiquitin-proteasome pathway. The CSN possesses a highly conserved dened
Externí odkaz:
https://doaj.org/article/fbc1b14234a84c2ea36ed90fe0bcd323
Autor:
Harriet M. Kluger, Yuval Kluger, David L. Rimm, Robert L. Camp, Lucia Jilaveanu, Christopher Zito, Elah Pick, Michael Davies, Saadia A. Aziz
Purpose: Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival, and are targets of drugs in clinical development. We assessed expression of PI3K in melanomas and nevi, and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f6c38738897858762975b93f308e93
https://doi.org/10.1158/1078-0432.c.6517614.v1
https://doi.org/10.1158/1078-0432.c.6517614.v1
Autor:
Harriet M. Kluger, Yuval Kluger, David L. Rimm, Robert L. Camp, Lucia Jilaveanu, Christopher Zito, Elah Pick, Michael Davies, Saadia A. Aziz
Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09499c13ce83c1d7d99e29c731179c8b
https://doi.org/10.1158/1078-0432.22440261.v1
https://doi.org/10.1158/1078-0432.22440261.v1