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Akademický článek

Phase II trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors SWOG/NCI experience: invasive mucinous or non-mucinous lepidic adenocarcinoma of the lung (formerly bronchioloalveolar carcinoma)

Autor: Young Kwang Chae, Megan Othus, Sandip Pravin Patel, David E. Gerber, Tawee Tanvetyanon, Hye Sung Kim, Liam Il-Young Chung, Christine M. McLeod, Gabby Lopez, Helen X. Chen, Elad Sharon, Howard Streicher, Cristopher W. Ryan, Charles D. Blanke, Razelle Kurzrock

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 16 (2024)

Background: Anti-programmed death-1 (PD-1)/cytotoxic T lymphocyte antigen-4 antibodies are efficacious in various malignancies. Objectives: This study presents the first results of ipilimumab–nivolumab in invasive mucinous or non-mucinous lepidic a

Externí odkaz: https://doaj.org/article/c89726aa1d404f1491a28f4c3b4cc7ad

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Akademický článek

Phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: the desmoid tumors

Autor: Howard Streicher, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Megan Othus, Sandip Patel, Christine McLeod, Charles Blanke, Benjamin Powers, Chung-Tsen Hsueh, Helen X Chen, Hye Sung Kim, Liam Il-Young Chung, Christopher W Ryan, Rangaswamy Govindarajan, Silvana Bucur

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)

Background Dual inhibition using anti-programmed death-1 (PD-1) and anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) checkpoint inhibitors has proven effective in many cancers. However, its efficacy in rare solid cancers remains unclear. Desmoid tumors

Externí odkaz: https://doaj.org/article/ae531706fd0f41aba22cfb80da0bf6da

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Akademický článek

Evolving patterns in systemic treatment utilization and survival among older patients with advanced cutaneous melanoma

Autor: Yoon Duk Hong, Lindsey Enewold, Elad Sharon, Jeremy L. Warner, Amy J. Davidoff, Chris Zeruto, Angela B. Mariotto

Publikováno v: Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)

Abstract Introduction In the last decade, melanoma treatment has improved significantly. However, data on population‐level treatment utilization and survival trends among older patients is limited. This study aimed to analyze trends in systemic ant

Externí odkaz: https://doaj.org/article/24383c045dce4e1aaa3f30064e40ca01

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Akademický článek

Phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: adrenocortical carcinoma cohort

Autor: Howard Streicher, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Benjamin Tan, Megan Othus, Christine McLeod, Charles Blanke, Helen X Chen, Sandip P Patel, Gabby Lopez, Tridu Huynh, Timothy Kuzel, Christopher W Ryan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)

Objectives Multiple common cancers benefit from immunotherapy; however, less is known about efficacy in rare tumors. We report the results of the adrenocortical carcinoma cohort of NCI/SWOG S1609 Dual Anti-CTLA-4 and Anti-PD-1 blockade in Rare Tumors

Externí odkaz: https://doaj.org/article/200c10085aef41019eb8269d72020f4d

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Akademický článek

Atezolizumab combined with immunogenic salvage chemoimmunotherapy in patients with transformed diffuse large B-cell lymphoma

Autor: Tamer Othman, Paul Frankel, Pamela Allen, Leslie L. Popplewell, Geoffrey Shouse, Tanya Siddiqi, Alexey V. Danilov, Nora Ruel, Shari Daniels, Lacolle Peters, Stella Khoo, Steven T. Rosen, Elad Sharon, Miguel Villalona-Calero, Christopher Ruel, Joseph Tuscano, Alex F. Herrera

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Patients with relapsed/refractory (R/R) transformed diffuse large B-cell lymphoma (DLBCL) from indolent B-cell lymphomas, including Richter transformation (RT), have a poor prognosis. PD-1/PD-L1 antibodies produce modest objective and complete respon

Externí odkaz: https://doaj.org/article/80f0e87d39424a2e83c6b1d56fb77f40

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Akademický článek

Using multi-scale genomics to associate poorly annotated genes with rare diseases

Autor: Christina Canavati, Dana Sherill-Rofe, Lara Kamal, Idit Bloch, Fouad Zahdeh, Elad Sharon, Batel Terespolsky, Islam Abu Allan, Grace Rabie, Mariana Kawas, Hanin Kassem, Karen B. Avraham, Paul Renbaum, Ephrat Levy-Lahad, Moien Kanaan, Yuval Tabach

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-22 (2024)

Abstract Background Next-generation sequencing (NGS) has significantly transformed the landscape of identifying disease-causing genes associated with genetic disorders. However, a substantial portion of sequenced patients remains undiagnosed. This ma

Externí odkaz: https://doaj.org/article/7a6f2b28ee0648df98cc0e6225b74bb8

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Akademický článek

Clinical outcomes and safety of immune checkpoint inhibitors in patients with solid tumors and paraneoplastic syndromes

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background Patients with paraneoplastic syndromes (PNS) are excluded from clinical trials involving immune checkpoint inhibitors (ICIs) due to safety concerns. Moreover, real-world data on efficacy and safety is scarce.Methods In this retrospective s

Externí odkaz: https://doaj.org/article/e3a36a44dc60429b90c5ae6bfb360660

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