Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Elad Chomsky"'
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that
Externí odkaz:
https://doaj.org/article/d4626884e3864b748b5d6fb020d26428
Autor:
Nimrod Rappoport, Elad Chomsky, Takashi Nagano, Charlie Seibert, Yaniv Lubling, Yael Baran, Aviezer Lifshitz, Wing Leung, Zohar Mukamel, Ron Shamir, Peter Fraser, Amos Tanay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Embryonic development involves massive proliferation and differentiation of cell lineages. This must be supported by chromosome replication and epigenetic reprogramming, but how proliferation and cell fate acquisition are balanced in this pr
Externí odkaz:
https://doaj.org/article/9405487864e141ed95c600dc5cb8ef6e
Autor:
Yael Baran, Akhiad Bercovich, Arnau Sebe-Pedros, Yaniv Lubling, Amir Giladi, Elad Chomsky, Zohar Meir, Michael Hoichman, Aviezer Lifshitz, Amos Tanay
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partiti
Externí odkaz:
https://doaj.org/article/9753d7773ac942dbb045658e3b7d0981
Autor:
Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J Nowell, Alex E Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R Griffis, Jonathan M Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A Croker, Natalia T Freund
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009165 (2021)
The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of COVID-19, we analyzed the B c
Externí odkaz:
https://doaj.org/article/0c87d14936274858891d55d77c97b63d
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-Seq and snRNA-Seq, scnRNA-Seq for short), can help characterize the composition of tissues and reveal cells that influence key functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d6e2658d4d1bada548c73ee791ec99
https://doi.org/10.1101/2022.12.13.520241
https://doi.org/10.1101/2022.12.13.520241
Autor:
Sébastien Bastide, Elad Chomsky, Baptiste Saudemont, Yann Loe-Mie, Sandrine Schmutz, Sophie Novault, Heather Marlow, Amos Tanay, François Spitz
Publikováno v:
Science Advances
Science Advances, 2022, 8 (50), ⟨10.1126/sciadv.add0695⟩
Science Advances, 2022, 8 (50), ⟨10.1126/sciadv.add0695⟩
International audience; The coordinated differentiation of progenitor cells into specialized cell types and their spatial organization into distinct domains is central to embryogenesis. Here, we developed and applied an unbiased spatially resolved si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eed3b3ea396bb3a2a86dc05efc3abb
https://doi.org/10.1126/sciadv.add0695
https://doi.org/10.1126/sciadv.add0695
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
Autor:
Kai-Oliver Henrich, Amos Tanay, Andres Quintero, Thomas G. P. Grunewald, Carl Herrmann, Umut H. Toprak, Elad Chomsky, Elisa M. Wecht, Ashwini Kumar Sharma, Thomas Höfer, Frank Westermann, A. Greco, Verena Körber, Selina Jansky, Moritz Gartlgruber
Publikováno v:
Nature Genetics. 53:683-693
Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the single-cell transcriptomes of neuroblastomas and normal human developing adrenal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9aa7d4a7a3a22f590435abb0e480185
https://doi.org/10.1038/s41588-021-00806-1
https://doi.org/10.1038/s41588-021-00806-1
Autor:
Sébastien Bastide, Elad Chomsky, Baptiste Saudemont, Yann Loe-Mie, Sandrine Schmutz, Sophie Novault, Heather Marlow, Amos Tanay, François Spitz
The coordinated differentiation of progenitor cells into specialized cell types and their spatial organization into distinct domains is central to embryogenesis. Here, we applied a new unbiased spatially resolved single-cell transcriptomics method to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c60c2ac3486f7f8f83a81259818a8b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03663882/file/2022.03.20.482385.full.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03663882/file/2022.03.20.482385.full.pdf
Publikováno v:
Nature genetics
Nature Genetics
Nature Genetics
Propagation of clonal regulatory programs contributes to cancer development. It is poorly understood how epigenetic mechanisms interact with genetic drivers to shape this process. Here, we combine single-cell analysis of transcription and DNA methyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c653f6b228977253482af9c65726f8c
https://doi.org/10.1038/s41588-020-0645-y
https://doi.org/10.1038/s41588-020-0645-y
Autor:
Zohar Mukamel, Aviezer Lifshitz, Markus Mittnenzweig, Elad Chomsky, Omer Schwartzman, Oren Ben-Kiki, Mirie Zerbib, Amos Tanay
Publikováno v:
Nature structuralmolecular biology.
In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies it across regulatory regions. Here we show that DNMT3A and DNMT3B are diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4c89a2887c1b4caf2c6e405d812765
https://pubmed.ncbi.nlm.nih.gov/36510023
https://pubmed.ncbi.nlm.nih.gov/36510023