An Analytical Approach Differentiates Between Individual and Collective Cancer Invasion

Autor: Elad Katz, Wim Verleyen, Colin G. Blackmore, Michael Edward, V. Anne Smith, David J. Harrison

Publikováno v: Analytical Cellular Pathology, Vol 34, Iss 1-2, Pp 35-48 (2011)

Tumour cells employ a variety of mechanisms to invade their environment and to form metastases. An important property is the ability of tumour cells to transition between individual cell invasive mode and collective mode. The switch from collective t

Externí odkaz: https://doaj.org/article/1a7744aed2d44623b6e08c188a0e2ae4

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer.

Autor: Elad Katz, Sylvie Dubois-Marshall, Andrew H Sims, Philippe Gautier, Helen Caldwell, Richard R Meehan, David J Harrison

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17083 (2011)

The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility. In human breast cancer, invasion into surround

Externí odkaz: https://doaj.org/article/1e79f3962f524db5a54b0e90f518ccab

Activation of estrogen-responsive genes does not require their nuclear co-localization.

Autor: Silvia Kocanova, Elizabeth A Kerr, Sehrish Rafique, Shelagh Boyle, Elad Katz, Stephanie Caze-Subra, Wendy A Bickmore, Kerstin Bystricky

Publikováno v: PLoS Genetics, Vol 6, Iss 4, p e1000922 (2010)

The spatial organization of the genome in the nucleus plays a role in the regulation of gene expression. Whether co-regulated genes are subject to coordinated repositioning to a shared nuclear space is a matter of considerable interest and debate. We

Externí odkaz: https://doaj.org/article/c6852ee376a240959bf18afad89d6fef

TMA Navigator: network inference, patient stratification and survival analysis with tissue microarray data

Autor: Ian M. Overton, Elad Katz, David J. Harrison, Alexander L. R. Lubbock

Publikováno v: Lubbock, A L R, Katz, E, Harrison, D J & Overton, I M 2013, ' TMA Navigator : network inference, patient stratification and survival analysis with tissue microarray data ', Nucleic Acids Research, vol. 41, no. W1, pp. W562-W568 . https://doi.org/10.1093/nar/gkt529
Nucleic Acids Research

Scottish Funding Council (SFC) and the Chief Scientist’s Office (CSO) (to D.H.); Royal Society of Edinburgh Scottish Government Fellowship co-funded by Marie Curie Actions and the UK Medical Research Council (MRC) (to I.O.). Funding for open access

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8ff98c71ab0e6531462cf0986d76be
https://doi.org/10.1093/nar/gkt529

WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel

Autor: Mara Artibani, Andrew H. Sims, Joan Slight, Stuart Aitken, Anna Thornburn, Morwenna Muir, Valerie G. Brunton, Jorge Del-Pozo, Linda R. Morrison, Elad Katz, Nicholas D. Hastie, Peter Hohenstein

Publikováno v: Scientific Reports
Artibani, M, Sims, A H, Slight, J, Aitken, S, Thornburn, A, Muir, M, Brunton, V G, Del-Pozo, J, Morrison, L R, Katz, E, Hastie, N D & Hohenstein, P 2017, ' WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel ', Scientific Reports, vol. 7, 45255 . https://doi.org/10.1038/srep45255

WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the most common paediatric kidney cancer. Its expression has also been reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b8809d57cc51aadacee564892cc235e4
https://pubmed.ncbi.nlm.nih.gov/28345629