Large-scale association analyses identify host factors influencing human gut microbiome composition

Autor: Jordana T. Bell, Sara Vieira-Silva, Torben Hansen, Andrew D. Paterson, Nicholas J. Timpson, Robert C. Kaplan, Vincent W. V. Jaddoe, Fabian Frost, Gwen Falony, Zachary D. Wallen, Mauro D'Amato, David A. Hughes, Jakob Stokholm, Lude Franke, Matthew A. Jackson, Marc Jan Bonder, Gonneke Willemsen, Dmitrii Borisevich, Hocheol Shin, Kyoko Watanabe, Annique Claringbould, Joanna Szopinska-Tokov, Markus M. Lerch, Caroline I. Le Roy, Markku Laakso, Eran Segal, Daisy Jonkers, Jee-Young Moon, Williams Turpin, Susanna Walter, Xingrong Liu, Lars Agréus, Tim D. Spector, Malte C. Rühlemann, Raul Y. Tito, Daniel Keszthelyi, Gareth E. Davies, Shiraz A. Shah, Ad A.M. Masclee, Carolina Medina-Gomez, Kreete Lüll, Robert D. Burk, Elin Org, Matthias Laudes, Cornelia M. van Duijn, Myriam Fornage, Urmo Võsa, Oluf Pedersen, Lenore J. Launer, Kaitlin H Wade, Juan Antonio Raygoza Garay, Rob Knight, Elad Barkan, Daria V. Zhernakova, Michael Boehnke, Frank Ulrich Weiss, Andre Franke, Jonathan Thorsen, Henry Völzke, Jingyuan Fu, Fernando Rivadeneira, Daphna Rothschild, Robert Kraaij, Katie A. Meyer, Ayse Demirkan, Claire J. Steves, Stefan Weiss, Cisca Wijmenga, Hans Bisgaard, Qi Qibin, Corinna Bang, Rodrigo Bacigalupe, Haydeh Payami, Han-Na Kim, Liesbeth Duijts, Alexander Kurilshikov, Serena Sanna, Kenneth Croitoru, Jeroen Raes, Djawad Radjabzadeh, Eco J. C. de Geus, Jun Wang, Richard G. IJzerman, Harm-Jan Westra, Uwe Völker, Torben Jørgensen, Dorret I. Boomsma, Omer Weissbrod, Alexandra Zhernakova, Alejandro Arias Vasquez, Casey T. Finnicum, Hyung Lae Kim, Marie Joossens, Tue H. Hansen, Henriette A. Moll, Anna Andreasson, Larbi Bedrani, Zlatan Mujagic, Adriaan van der Graaf, Søren J. Sørensen, Aldons J. Lusis, Wolfgang Lieb, Georg Homuth, André G. Uitterlinden

Publikováno v: Nature Genetics, 53, 2, pp. 156-165
Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J-Y, Kim, H-N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S R J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H-J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H-L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1
Nature Genetics, 53(2), 156-165. Nature Publishing Group
Nat Genet
Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J, Zhernakova, A & MiBioGen Consortium Initiative 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1
Nature Genetics
Nature Genetics, 53, 156-165
Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1
Nature genetics, vol 53, iss 2
Nature Genetics, 53, 156-165. Nature Publishing Group
Kurilshikov, A, Hughes, D A, Timpson, N J, Wade, K H, Zhernakova, A & et al. 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1

Contains fulltext : 231681.pdf (Publisher’s version ) (Closed access) To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2e8f48d9f4a1a7f6864962650bb03d
https://hdl.handle.net/2066/231681

Comparison of SARS-CoV-2 Exit Strategies Building Blocks

Autor: Smadar Shilo, Elad Barkan, Yeela Talmor-Barkan

We consider and compare various exit strategy building blocks and key measures to mitigate the current SARS-CoV-2 pandemic, some already proposed as well as improvements we suggest. Our comparison is based on a computerized simulation integrating acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3a59bf784bf9a7a8f1537e9caf7259

Environment dominates over host genetics in shaping human gut microbiota

Autor: Anastasia Godneva, Elad Barkan, Tal Korem, Alexander Kurilshikov, Iris N. Kalka, David Zeevi, Paul I. Costea, Daphna Rothschild, Omer Weissbrod, Noam Bar

Publikováno v: Yearbook of Paediatric Endocrinology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3273f922f63b93605505897929987fc5
https://doi.org/10.1530/ey.15.14.5

Environmental factors dominate over host genetics in shaping human gut microbiota composition

Autor: Bat Chen Wolf, Tal Korem, Daphna Rothschild, Eran Elinav, Meirav Pevsner-Fischer, Anastasia Godneva, David Zeevi, Paul I. Costea, Eran Segal, Elad Barkan, Noa Kosower, Maya Lotan-Pompan, Niv Zmora, Iris N. Kalka, Tali Avnit-Sagi, Noam Bar, Shai Carmi, David Israeli, Omer Weissbrod, Zamir Halpern, Gal Malka, Adina Weinberger

Human gut microbiome composition is shaped by multiple host intrinsic and extrinsic factors, but the relative contribution of host genetic compared to environmental factors remains elusive. Here, we genotyped a cohort of 696 healthy individuals from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0dcceba81882c5b63b3cecf79d66f
https://doi.org/10.1101/150540

Rigorous Bounds on Cryptanalytic Time/Memory Tradeoffs

Autor: Elad Barkan, Eli Biham, Adi Shamir

Publikováno v: Lecture Notes in Computer Science ISBN: 9783540374329
CRYPTO

In this paper we formalize a general model of cryptanalytic time/memory tradeoffs for the inversion of a random function f:{0,1,..., N–1} ↦{0,1,..., N–1}. The model contains all the known tradeoff techniques as special cases. It is based on a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::279176b415c9b74f588a765b41fbdddc
https://doi.org/10.1007/11818175_1