Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ela Karshovska"'
Autor:
Ela Karshovska, Rokia Mohibullah, Mengyu Zhu, Farima Zahedi, Dominique Thomas, Christiana Magkrioti, Claudia Geissler, Remco T.A. Megens, Mariaelvy Bianchini, Maliheh Nazari-Jahantigh, Nerea Ferreirós, Vassilis Aidinis, Andreas Schober
Publikováno v:
Arteriosclerosis Thrombosis and Vascular Biology, 42(8), 1023-1036. LIPPINCOTT WILLIAMS & WILKINS
Background: Maladapted endothelial cells (ECs) secrete ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxin)—a lysophospholipase D that generates lysophosphatidic acids (LPAs). ENPP2 derived from the arterial wall promotes atherogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df96943065c948c9b7180f35e556573
https://doi.org/10.1161/ATVBAHA.122.317682
https://doi.org/10.1161/ATVBAHA.122.317682
Autor:
Andreas Schober, Ela Karshovska, Isabelle Baatsch, Rokia Mohibullah, Yuanyuan Wei, Nicole Exner, Claudia Geißler, Pallavi Subramanian, Aamoun Popal, Judit Corbalán Campos
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology 40(3), 583-596 (2020). doi:10.1161/ATVBAHA.119.313290
Objective: Inflammatory activation changes the mitochondrial function of macrophages from oxidative phosphorylation to reactive oxygen species production, which may promote necrotic core formation in atherosclerotic lesions. In hypoxic and cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb446a9070d1fc760c894872cac817e
https://pubmed.ncbi.nlm.nih.gov/31996026
https://pubmed.ncbi.nlm.nih.gov/31996026
Autor:
Mengyu Zhu, Ela Karshovska, Michael Hristov, Claudia Geißler, Judit Corbalán Campos, Kathrin Abschlag, Michael Lehrke, Andreas Schober, Julia Möllmann, Yuanyuan Wei
Publikováno v:
Diabetes. 66:3072-3084
A high-fat diet increases bacterial lipopolysaccharide (LPS) in the circulation and thereby stimulates glucagon-like peptide 1 (GLP-1)–mediated insulin secretion by upregulating interleukin-6 (IL-6). Although microRNA-155-5p (miR-155-5p), which inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07700d7f12cb81f1364bf8b7ebdd0b6
https://doi.org/10.2337/db17-0313
https://doi.org/10.2337/db17-0313
Autor:
Annemiek Dickhout, Christian Weber, Martin Schmitt, Rory R. Koenen, Zhen Zhao, Remco T. A. Megens, Thomas A. Koeppel, Tilman M. Hackeng, Tanja Vajen, Philipp von Hundelshausen, Ela Karshovska
Publikováno v:
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 21(8), 1523-1531. Wiley-Blackwell
Journal of Cellular and Molecular Medicine, 21(8), 1523-1531. Wiley-Blackwell
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8803a7135e056ff9132d72f83ee4e9
https://doi.org/10.1111/jcmm.13083
https://doi.org/10.1111/jcmm.13083
Autor:
Michael J. Jacobs, Christian Weber, Fabian Kiessling, Shamima Akhtar, Andreas Schober, Ela Karshovska, Sabine Steffens, Pallavi Subramanian, Felix Gremse, Fatuma-Ayaan Rinderknecht, Jochen Grommes, Petra Hartmann
Publikováno v:
Hypertension, 66(6), 1220-1226. LIPPINCOTT WILLIAMS & WILKINS
Chemokines mediate monocyte adhesion to dysfunctional endothelial cells (ECs) and promote arterial inflammation during atherosclerosis. Hypoxia-inducible factor (HIF)-1α is expressed in various cell types of atherosclerotic lesions and is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50b3429ea6142911b6c2f14309d99db
https://doi.org/10.1161/HYPERTENSIONAHA.115.05886
https://doi.org/10.1161/HYPERTENSIONAHA.115.05886
Autor:
Kiril Bidzhekov, Andreas Schober, Martin Schmitt, Rory R. Koenen, Christian Weber, Tilman M. Hackeng, Philipp von Hundelshausen, Xavier Blanchet, Thomas A. Koeppel, Nadine J.A. Mattheij, Remco T. A. Megens, Zhen Zhao, Oliver Soehnlein, Judith M.E.M. Cosemans, Ela Karshovska
Publikováno v:
Circulation research, 116(4), 587-599. Lippincott Williams and Wilkins
Circulation Research, 116(4), 587-599. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 116(4), 587-599. LIPPINCOTT WILLIAMS & WILKINS
Rationale: Besides their essential role in hemostasis, platelets also have functions in inflammation. In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin α IIb β 3 -mediated outside-in signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ec0443d2ea79bb37586cf3b77f362d
https://doi.org/10.1161/CIRCRESAHA.116.304035
https://doi.org/10.1161/CIRCRESAHA.116.304035
Autor:
Helga D. Manthey, Martin Busch, Christian Weber, Alma Zernecke, Jaroslav Pelisek, Ela Karshovska, Miriam Koch, Stefanie Barnsteiner, Rory R. Koenen, Hans-Henning Eckstein, Clément Cochain, Sweena M. Chaudhari
Publikováno v:
Thrombosis and Haemostasis, 110(6), 1267-77. Georg Thieme Verlag
SummaryThe chemokine receptor CCR6 is expressed by various cell subsets implicated in atherogenesis, such as monocytes, Th17 and regulatory T cells. In order to further define the role of CCR6 in atherosclerosis, CCR6-deficient (Ccr6 -/-) mice were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a087bd2b0aecfab3cd059fae174b81a
https://doi.org/10.1160/th13-01-0017
https://doi.org/10.1160/th13-01-0017
Autor:
Ela Karshovska, Andreas Schober
Publikováno v:
Drug Discovery Today: Disease Mechanisms. 5:e293-e298
The arterial vessel wall uniformly reacts to different kinds of injuries with structural changes characterized by neointimal formation, medial hypertrophy and constrictive remodeling leading to luminal stenosis. This detrimental sequela of vascular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ec65f972cac7cb42ca8cd1a465a827
https://doi.org/10.1016/j.ddmec.2008.10.003
https://doi.org/10.1016/j.ddmec.2008.10.003
Autor:
Mihail Hristov, Christian Weber, Alma Zernecke, Andrea Millet, Volker Klauss, Hae-Young Sohn, Gueler Sevilmis, Holger Schmid, Andreas Schober, Ela Karshovska, Clemens D. Cohen, Florian Krötz
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:2540-2547
Objective— Hypoxia-inducible factor (HIF)-1α is the regulatory subunit of a transcriptional complex, which controls the recruitment of multipotent progenitor cells and tissue repair in ischemic tissue by inducing stromal cell-derived factor (SDF)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4df0b5d7b9ef30e3f6f0f61994f86e5
https://doi.org/10.1161/atvbaha.107.151050
https://doi.org/10.1161/atvbaha.107.151050
Autor:
Helmut Küchenhoff, Christian Weber, Xavier Blanchet, Daniel Teupser, Sebastian F. Mause, K. Cesarek, Hermann E. Wasmuth, Heiko Herwald, Rory R. Koenen, Ela Karshovska, J. Brandt, Oliver Soehnlein, Wolfgang Siess, P. von Hundelshausen
Publikováno v:
Thrombosis and haemostasis, 112(6), 1277-1287. Schattauer GmbH
Thrombosis and Haemostasis, 112(6), 1277-1287. Georg Thieme Verlag
Thrombosis and Haemostasis, 112(6), 1277-1287. Georg Thieme Verlag
SummaryActivated platelets and neutrophils exacerbate atherosclerosis. Platelets release the chemokines CXCL4, CXCL4L1 and CCL5, whereas myeloperoxidase (MPO) and azurocidin are neutrophil-derived. We investigated whether plasma levels of these plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b72965dfa45bddaffe7ea2e159d78
https://pure.amc.nl/en/publications/inflammatory-role-and-prognostic-value-of-platelet-chemokines-in-acute-coronary-syndrome(488bad1b-fcdf-4a7f-a5b5-a05e0d859992).html
https://pure.amc.nl/en/publications/inflammatory-role-and-prognostic-value-of-platelet-chemokines-in-acute-coronary-syndrome(488bad1b-fcdf-4a7f-a5b5-a05e0d859992).html
