A dual-targeted drug inhibits cardiac ryanodine receptor Ca ²⁺ leak but activates SERCA2a Ca ²⁺ uptake.

Autor: Wegener JW; Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany joerg.wegener@med.uni-goettingen.de.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Mitronova GY; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., ElShareif L; Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany., Quentin C; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Belov V; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Pochechueva T; Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Hasenfuss G; Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Ackermann L; Georg-August University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Lehnart SE; Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany slehnart@med.uni-goettingen.de.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Nov 27; Vol. 7 (2). Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2024).