Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs.

Autor: Zhang H; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., McCarroll A; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Peyton L; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Díaz de León-Guerrerro S; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Zhang S; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Gowda P; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Sirkin D; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., ElAchwah M; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Duhe A; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Wood WG; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Jamison B; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Tracy G; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA., Pollak R; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA., Hart RP; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA., Pato CN; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA., Mulle JG; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Sanders AR; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Pang ZP; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Electronic address: pangzh@rwjms.rutgers.edu., Duan J; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA. Electronic address: jduan@uchicago.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Oct 08; Vol. 19 (10), pp. 1489-1504. Date of Electronic Publication: 2024 Sep 12.