Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis.

Autor: El-Deeb AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt., Mohamed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt. Electronic address: ahmed.fathi@pharma.cu.edu.eg., El-Yamany MF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt., El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2023 Aug 01; Vol. 380, pp. 110562. Date of Electronic Publication: 2023 May 22.

Apigenin attenuates LPS-induced neurotoxicity and cognitive impairment in mice via promoting mitochondrial fusion/mitophagy: role of SIRT3/PINK1/Parkin pathway.

Autor: Ahmedy OA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. omaima.ali@pharma.cu.edu.eg., Abdelghany TM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.; School of Biomedical, Nutritional and Sport Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE24HH, UK.; Institute of Translational and Clinical Research, Newcastle University, Newcastle Upon Tyne, NE24HH, UK., El-Shamarka MEA; Department of Narcotics, Ergogenic Aids and Poisons, Medical Research Division, National Research Center, Cairo, 12622, Egypt., Khattab MA; Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Cairo, 12211, Egypt., El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

Publikováno v: Psychopharmacology [Psychopharmacology (Berl)] 2022 Dec; Vol. 239 (12), pp. 3903-3917. Date of Electronic Publication: 2022 Oct 26.

Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease.

Autor: El-Deeb NK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt., El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt. Electronic address: dalia.eltanbouly@pharma.cu.edu.eg., Khattab MA; Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, 12211, Egypt., El-Yamany MF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt., Mohamed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Egypt.

Publikováno v: International immunopharmacology [Int Immunopharmacol] 2022 Nov; Vol. 112, pp. 109191. Date of Electronic Publication: 2022 Aug 30.

Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: Modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects.

Autor: Hussien YA; Pharmacology Department, Medical Research and Clinical Institute - National Research Centre, Giza, Egypt., Mansour DF; Pharmacology Department, Medical Research and Clinical Institute - National Research Centre, Giza, Egypt., Nada SA; Pharmacology Department, Medical Research and Clinical Institute - National Research Centre, Giza, Egypt., Abd El-Rahman SS; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Abdelsalam RM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Biology Department, School of Pharmacy, New Giza University, Giza, Egypt., Attia AS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., El-Tanbouly DM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: dalia.eltanbouly@pharma.cu.edu.eg.

Publikováno v: Life sciences [Life Sci] 2022 Apr 15; Vol. 295, pp. 120378. Date of Electronic Publication: 2022 Feb 05.

Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89.

Autor: Ashour NH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt., El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt., El Sayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: nesrine.salah@pharma.cu.edu.eg., Khattab MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Publikováno v: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2021 Dec 20; Vol. 111, pp. 110366. Date of Electronic Publication: 2021 May 26.