Zobrazeno 1 - 10
of 16
pro vyhledávání: '"El-Shimaa M.N. Abdelhafez"'
Autor:
M. M. Badr, Mona S. El-Zoghbi, Amr K.A. Bass, El-Shimaa M.N. Abdelhafez, Mamdouh F.A. Mohamed, Gamal El-Din A. Abuo-Rahma
Publikováno v:
Journal of advanced Biomedical and Pharmaceutical Sciences. 4:81-86
Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as natural products and formed the integral backbone of great number of drugs in the market. In particular, 3-cyano-2-oxa-pyridines showed diverse biological and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80898a20691858cb1169e1897a193b9e
https://doi.org/10.21608/jabps.2020.52641.1113
https://doi.org/10.21608/jabps.2020.52641.1113
Autor:
Satoshi Mitarai, James M. Berger, Masayoshi Arai, Samar H. Abbas, Hamada H.H. Mohammed, Gamal El-Din A. Abuo-Rahma, El-Shimaa M.N. Abdelhafez
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 150:1809-1824
Herein we report the synthesis of new N-4-piperazinyl thiadiazole and oxadiazole ciprofloxacin derivatives and their antibacterial and antimycobacterial activities. Although thiadiazole ciprofloxacin derivatives compound showed broad spectrum antibac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6898818d922d1ff16648f6ec26a0f0b
https://doi.org/10.1007/s00706-019-02478-4
https://doi.org/10.1007/s00706-019-02478-4
Autor:
Essmat M. El-Sheref, Martin Nieger, Ashraf A. Aly, Stefan Bräse, El-Shimaa M.N. Abdelhafez, Alan B. Brown
Publikováno v:
Journal of Sulfur Chemistry. 40:641-647
A new one pot reaction of substituted thiosemicarbazides with 2-bromoacetophenone and carbonyl compounds gave 2-hydrazonothiazoles in good yields. The structures of the isolated compounds were corroborated by NMR, IR, mass spectra and elemental analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0767a49b0ee6bd4836c231084e3e4c5
https://doi.org/10.1080/17415993.2019.1635132
https://doi.org/10.1080/17415993.2019.1635132
Autor:
Tamer S. Kaoud, Nasr K. Mohamed, Stefan Bräse, Kamal M. El Shaieb, Alaa A. Hassan, Kevin N. Dalby, El-Shimaa M.N. Abdelhafez, Martin Nieger, Ashraf A. Aly, Maysa M. Makhlouf
Publikováno v:
Bioorganic Chemistry. 85:585-599
A large number of natural products containing the propellane scaffold have been reported to exhibit cytotoxicity against several cancers; however, their mechanism of action is still unknown. Anticancer drugs targeting DNA are mainly composed of small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bf6a3a5d084aa454b3bc5ffebb61fc
https://doi.org/10.1016/j.bioorg.2019.02.027
https://doi.org/10.1016/j.bioorg.2019.02.027
Autor:
Martha M. Morcoss, Reham Ali Ibrahem, Mohamed Abdel-Aziz, El-Shimaa M.N. Abdelhafez, Hamdy M. Abdel-Rahman, Dalal A. Abou El-Ella
Publikováno v:
Bioorganic chemistry. 101
Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1,2,4-triazole and 1,3,4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and evaluated for their antimicrobial activity. The structures of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fdeb4d18e3f4d2e02ffae7d9032bba
https://pubmed.ncbi.nlm.nih.gov/32512267
https://pubmed.ncbi.nlm.nih.gov/32512267
Autor:
Mohamed Abdel-Aziz, Dalal A. Abou El-Ella, El-Shimaa M.N. Abdelhafez, Martha M. Morcoss, Hamdy M. Abdel-Rahman
Publikováno v:
Journal of advanced Biomedical and Pharmaceutical Sciences.
A novel series of benzimidazole-hydrazone derivatives was designed and synthesized as a potential anti-cancer agents. The structure of the target compounds was assured using different spectroscopic methods such as IR , 1H NMR, 13C NMR and elemental a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad0bb7e11f92054544e438a19250bb54
https://doi.org/10.21608/jabps.2020.21160.1064
https://doi.org/10.21608/jabps.2020.21160.1064
Autor:
Dalia Abdelhamid, Muhamad Mustafa, El-Shimaa M.N. Abdelhafez, Mahmoud A. A. Ibrahim, Omar M. Aly, Amira M. Gamal-Eldeen
Publikováno v:
European Journal of Medicinal Chemistry. 141:293-305
Combretastatin A4 (CA4) is a natural product characterized by a powerful inhibition of tubulin polymerization and a potential anticancer activity. However, therapeutic application of CA4 is substantially hindered due to geometric isomerization. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892144ebb216dbd3b3e3859e19c781d3
https://doi.org/10.1016/j.ejmech.2017.09.063
https://doi.org/10.1016/j.ejmech.2017.09.063
Autor:
Rehab Mahmoud Abd El-Baky, Mohammed A. A. Abdullah, Heba A. Hassan, El-Shimaa M.N. Abdelhafez, Gamal El-Din A. Abuo-Rahma
Publikováno v:
Bioorganic Chemistry. 70:1-11
New hydroxamic acid, hydrazide and amide derivatives of ciprofloxacin in addition to their analogues of levofloxacin were prepared and identified by different spectroscopic techniques. Some of the prepared compounds revealed good activity against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2177c8bf9da8bfe66bef385000466cb0
https://doi.org/10.1016/j.bioorg.2016.11.002
https://doi.org/10.1016/j.bioorg.2016.11.002
Publikováno v:
Bioorganic chemistry. 99
Bis-hydrazides 13a-h were designed and synthesized as potential tubulin inhibitors selectively targeting the colchicine site between α- and β-tubulin subunits. The newly designed ring-B substituents were assisted at their ends by ‘anchor groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4189250a4877d0f9667fb6055c4934
https://pubmed.ncbi.nlm.nih.gov/32325332
https://pubmed.ncbi.nlm.nih.gov/32325332
Autor:
Mohamed Ramadan Eisa Hassan, Sara Mohamed Naguib Abdelhafez Ali, El-Shimaa M.N. Abdelhafez, Adel M. Abdel-Hakem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bc43e0a4d4d438ab0cbdd9db069e9c
http://www.intechopen.com/articles/show/title/apoptotic-inhibitors-as-therapeutic-targets-for-cell-survival
http://www.intechopen.com/articles/show/title/apoptotic-inhibitors-as-therapeutic-targets-for-cell-survival
