Novel pyrimidine derivatives and black cumin as xanthine oxidase inhibitors: Synthesis, docking study and formulation.

Autor: Ahjel SW; Pharmacy Department, Al-Zahrawi University College, Karbala, Iraq., Humadi SS; Pharmacy Department, Al-Zahrawi University College, Karbala, Iraq., Mohamed Awad S; Pharmacy Department, Al-Zahrawi University College, Karbala, Iraq/Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan, Egypt., El-Shehry MF; Pharmacy Department, Al-Zahrawi University College, Karbala, Iraq/Pesticides Chemistry Department, National Research Centre, Dokki, Giza, Egypt., Mansour YE; Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan, Egypt., El-Rashedy AAE; Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Giza, Egypt.

Publikováno v: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2024 Sep; Vol. 37 (5), pp. 1151-1161.

Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19.

Autor: Mahgoub S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt. Electronic address: Shahenda.Mahgoub@pharm.helwan.edu.eg., Fatahala SS; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box 11795, Helwan, Cairo, Egypt. Electronic address: Samar_Saleh@pharm.helwan.edu.eg., Sayed AI; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box 11795, Helwan, Cairo, Egypt., Atya HB; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt., El-Shehry MF; Pesticide Chemistry Department, National Research Centre, P.O. Box 12622, Dokki, Egypt., Afifi H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University, Egypt; Department of Pharmacy, City University College of Ajman, UAE., Awad SM; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box 11795, Helwan, Cairo, Egypt., El-Hameed RHA; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box 11795, Helwan, Cairo, Egypt., Taha H; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Nov; Vol. 128, pp. 106092. Date of Electronic Publication: 2022 Aug 10.

Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors.

Autor: El-Sayed NF; Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), Dokki, Giza, P.O. 12622, Egypt., El-Hussieny M; Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), Dokki, Giza, P.O. 12622, Egypt., Ewies EF; Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), Dokki, Giza, P.O. 12622, Egypt., El Shehry MF; Pesticide Chemistry Department, National Research Centre, Giza, Egypt., Awad HM; Department of Tanning Materials and Leather Technology, National Research Centre, Giza, Egypt., Fouad MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt.; Pharmaceutical Chemistry Department, School of Pharmacy, New Giza University, Cairo, Egypt.

Publikováno v: Drug development research [Drug Dev Res] 2022 Apr; Vol. 83 (2), pp. 485-500. Date of Electronic Publication: 2021 Sep 15.

Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19.

Autor: Mahgoub S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, P.O. Box, 11795 Cairo, Egypt. Electronic address: Shahenda.Mahgoub@pharm.helwan.edu.eg., Kotb El-Sayed MI; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, P.O. Box, 11795 Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., El-Shehry MF; Pesticide Chemistry Department, National Research Centre, P.O. Box, 12622 Dokki, Egypt., Mohamed Awad S; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box, 11795 Cairo, Egypt., Mansour YE; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box, 11795 Cairo, Egypt., Fatahala SS; Pharmaceutical Organic Chemistry Department, Helwan University, P.O. Box, 11795 Cairo, Egypt. Electronic address: Samar_Saleh@pharm.helwan.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Nov; Vol. 116, pp. 105272. Date of Electronic Publication: 2021 Aug 24.

In Vitro and In Vivo Anti-Breast Cancer Activities of Some Newly Synthesized 5-(thiophen-2-yl)thieno-[2,3-d]pyrimidin-4-one Candidates.

Autor: Amr AEE; Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. aamr@ksu.edu.sa.; Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12622, Egypt. aamr@ksu.edu.sa., Ibrahimd AA; Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12622, Egypt. alhusseina62@yahoo.com., El-Shehry MF; Pesticide Chemistry Department, National Research Center, Dokki 12622, Cairo, Egypt. hanaanrc@yahoo.com.; Chemistry Department, Al-Zahrawy University College, Karbala 56001, Iraq. hanaanrc@yahoo.com., Hosni HM; Pesticide Chemistry Department, National Research Center, Dokki 12622, Cairo, Egypt. hanaahosni434@yahoo.com., Fayed AA; Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12622, Egypt. dr_ahmedfayed14@yahoo.com.; Respiratory Therapy Department, College of Medical Rehabilitation Sciences, Taibah University, Madinah Munawara, 22624, Saudi Arabia. dr_ahmedfayed14@yahoo.com., Elsayed EA; Zoology Department, Bioproducts Research Chair, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia. eaelsayed@ksu.edu.sa.; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki 12622, Cairo, Egypt. eaelsayed@ksu.edu.sa.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2019 Jun 17; Vol. 24 (12). Date of Electronic Publication: 2019 Jun 17.