Výsledky vyhledávání - "El-Sayed A. M. Badawey"

Design and synthesis of some β-carboline derivatives as multi-target anticancer agents

Autor: Mai S. El-Shoukrofy, Mohamed A Abdelsalam, El-Sayed A. M. Badawey, Noha Gouda, Omaima M. Aboulwafa, Mostafa M.M. El-Miligy

Publikováno v: Future Medicinal Chemistry. 10:2791-2814

Aim: Some anticancer β-carbolines exhibited dual inhibition of topo-I and KSP. Methodology/Results: Novel β-carbolines were synthesized and screened for their anticancer activity according to the NCI protocol. Five dose assays results indicated tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3a64d022e3d2f543ca30ea7cc21afa
https://doi.org/10.4155/fmc-2018-0226

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Design, synthesis, anticancer screening, docking studies and in silico ADME prediction of some β-carboline derivatives

Autor: Omaima M. Aboulwafa, Mahmoud M. Elaasser, Mai S. El-Shoukrofy, Mohamed A Abdelsalam, El-Sayed A. M. Badawey, Mostafa M.M. El-Miligy, Noha Gouda

Publikováno v: Future medicinal chemistry. 10(10)

Background: Medicinal interest has focused on β-carbolines as anticancer agents. Methodology/Results: Several β-carbolines were designed, synthesized and evaluated for their cytotoxic activity against MCF-7 and A-549 cancer cell lines using MTT ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6bebf96c183c65d1570ae45ca566b2
https://pubmed.ncbi.nlm.nih.gov/29787297

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Nonsteroidal antiinflammatory agents—part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones

Autor: El-Sayed A. M. Badawey, Ibrahim M. El-Ashmawey, Soad A.M. El-Hawash

Publikováno v: European Journal of Medicinal Chemistry. 41:155-165

As a part of a research project on the synthesis of a number of substituted 1-(pyrimidin-2-yl)-3-pyrazolin-5-ones and 2-(pyrimidin-2-yl)hexahydroindazol-3-ones and as a result of the interesting antiinflammatory, analgesic and antipyretic activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f81ce04c0d7de51fc096180d9a595d
https://doi.org/10.1016/j.ejmech.2005.09.006

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Malonates in Cyclocondensation Reactions

Autor: Thomas Kappe, Peter Roschger, Gerhard Hojas, El-Sayed A. M. Badawey, Wolfgang Stadlbauer

Publikováno v: Molecules, Vol 6, Iss 4, Pp 338-352 (2001)
Molecules
Volume 6
Issue 4
Pages 338-352
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

The use of malonates such as diethyl malonates 9, (chlorocarbonyl)ketenes 15 and bis(2,4,6-trichlorophenyl) malonates 18 as reagents for cyclocondensation with 1,3-dinucleophiles to give six-membered heterocycles is described. Further attempts to use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6474a5f2b7a2dcb6a085fab6d5adf48e
http://www.mdpi.com/1420-3049/6/4/338/

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Benzimidazole condensed ring systems. XI. Synthesis of some substituted cycloalkyl pyrido[1,2-a]benzimidazoles with anticipated antineoplastic activity##This work was partly presented in the 6th Ibn Sina International Conference on pure and applied Heterocyclic Chemistry, December, 1997. For part X, see ref. [4]

Autor: Thomas Kappe, El-Sayed A. M. Badawey

Publikováno v: European Journal of Medicinal Chemistry. 34:663-667

As part of a research project on the synthesis of a number of pyrido[1,2-a]benzimidazole derivatives with possible antineoplastic activity, and as a result of the interesting antineoplastic activity recorded for one such compound (NSC 649900), some n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::490953eb90b90f5bfb6e4c44d89dc17d
https://doi.org/10.1016/s0223-5234(00)80036-7

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Nonsteroidal antiinflammatory agents - Part 1: Antiinflammatory, analgesic and antipyretic activity of some new 1-(pyrimidin-2-yl)-3-pyrazolin-5-ones and 2-(pyrimidin-2-yl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-ones

Autor: Ibrahim M. El-Ashmawey, El-Sayed A. M. Badawey

Publikováno v: European Journal of Medicinal Chemistry. 33:349-361

In our reinvestigation of the cyclocondensation reaction of aminoguanidine bicarbonate 1 with 2-acetylbutyrolactone 2 and ethyl cyclohexanone-2-carboxylate 6 , we have obtained the respective 1-amidino-3-pyrazolin-5-one derivative 3 and the 2-amidino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b497c91edda4c6603ccc1821d00c4d49
https://doi.org/10.1016/s0223-5234(98)80002-0

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Condensed thiazoles, I: Synthesis of 5,7-disubstituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents

Autor: Hesham Fahmy, S. M. Rida, N. S. Habib, El-Sayed A. M. Badawey

Publikováno v: Monatshefte f�r Chemie Chemical Monthly. 127:1203-1207

A convenient and simple synthesis of 5-mercapto-3-phenyl-2-thioxo-2,3-dihydrothiazolo-[4,5-d]pyrimidin-7(6H-one(2) and its 5,7-dichloro (3), 5,7-diazido (4), 5,7-diamino (5), 5,7-dimerapto (6), 5,7-dimethylthio (7), and 6-methyl-5-methylthio (8) deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3160f770339daec40aaeb916b2e55e3d
https://doi.org/10.1007/bf00844696

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Synthesis andin vitroevaluation of some new pyrimidines and related condensed ring systems as potential anticancer agents

Autor: El-Sayed A. M. Badawey

Publikováno v: Journal of Heterocyclic Chemistry. 33:229-233

Several new pyrimidines 6–11, 18–20, furo-, thieno-, and pyrrolo[2,3-d]pyrimidines 3, 8, 12, triazolo-[4,3-a]pyrimidines 14, 15, 16 and tetrazolo[1,5-a]pyrimidine 17 were prepared from the known intermediate 5-(2-hydroxyethyl)-6-methyl-2-thiourac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa50c8df758f25ccad0dbde5727cf4a4
https://doi.org/10.1002/jhet.5570330202

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Synthesis of some new imidazo[1,2-a]pyrimidin-5(1H)-ones as potential antineoplastic agents

Autor: El-Sayed A. M. Badawey, Thomas Kappe

Publikováno v: Journal of Heterocyclic Chemistry. 32:1003-1006

Some substituted imidazo[1,2-a]pyrimidin-5(1H)-ones have been synthesized via the reaction of 2-aminoimidazole sulfate with some β-keto esters, diethyl ethoxymethylenemalonate and ethyl ethoxymethylenecyanoacetate. Several compounds were screened fo

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https://doi.org/10.1002/jhet.5570320355

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Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-α]benzimidazoles and related derivative

Autor: Thomas Kappe, El-Sayed A. M. Badawey

Publikováno v: European Journal of Medicinal Chemistry. 30:327-332

Summary Some pyrido[1,2-a]benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities. Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67f5b31f3411dd9dd203ad50fc644c3d
https://doi.org/10.1016/0223-5234(96)88241-9

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