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In vitro and in silico evaluation of new thieno[2,3-d]pyrimidines as anti-cancer agents and apoptosis inducers targeting VEGFR-2.

Autor: El-Metwally SA; Department of Basic Science, Higher Technological institute, 10th of Ramadan City, Egypt., Abuelkhir AA; Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Cairo 12613, Egypt., Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Sultan A; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Ismail A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt., Elkhawaga SY; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia. Electronic address: ikaeed@mcst.edu.sa., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt. Electronic address: ametwaly@azhar.edu.eg., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.

Publikováno v: Computational biology and chemistry [Comput Biol Chem] 2023 Oct; Vol. 106, pp. 107928. Date of Electronic Publication: 2023 Jul 18.

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies.

Autor: Gaber AA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Sobhy M; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Turky A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., El-Sebaey SA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., El-Metwally SA; Department of Basic Science, Higher Technological institute, 10th of Ramadan City, Egypt., El-Naggar AM; Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, Cairo, Egypt., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh, Saudi Arabia., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

Publikováno v: PloS one [PLoS One] 2023 Jan 30; Vol. 18 (1), pp. e0274081. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).

Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents.

Autor: El-Metwally SA; Department of Basic Science, Higher Technological Institute, 10th of Ramadan City 228, Egypt., Abou-El-Regal MM; Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: ibrahimeissa@azhar.edu.eg., Mehany ABM; Department of Zoology, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt., Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Riyadh, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: eslamkaeed@azhar.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104947. Date of Electronic Publication: 2021 Apr 27.

Novel Tetrahydrobenzo [b] Thiophene Compounds Exhibit Anticancer Activity through Enhancing Apoptosis and Inhibiting Tyrosine Kinase.

Autor: El-Metwally SA; Higher Technological Institute, 10th of Ramadan city 44629, Egypt., Khalil AK; Chemistry Department, Faculty of Science, Ain shams University, Abbassia, Cairo, 11566, Egypt., El-Naggar AM; Chemistry Department, Faculty of Science, Ain shams University, Abbassia, Cairo, 11566, Egypt., El-Sayed WM; Department of Zoology, University of Ain Shams, Faculty of Science, Abbassia 11566, Cairo, Egypt.

Publikováno v: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2018; Vol. 18 (12), pp. 1761-1769.