WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway.

Autor: Elewa MAF; Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, Egypt., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt., Hamdan AME; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Abd El-Kawi SH; Department of Medical Histology and Cell Biology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., El-Kalaawy AM; Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Majrashi TA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Barghash RF; Institute of Chemical Industries Research, National Research Centre, Dokki, Giza, Egypt., Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Giza, Egypt., Hashem KS; Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt., Al-Gayyar MMH; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2185761.

Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways.

Autor: Yassin NYS; Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt., AbouZid SF; Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo-Belbeis Desert Road, P.O. Box 3020 El Salam, 11785 Cairo, Egypt., El-Kalaawy AM; Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Ali TM; Department of Physiology, College of Medicine, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia., Almehmadi MM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia., Ahmed OM; Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt. Electronic address: osamamoha@yahoo.com.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jan; Vol. 145, pp. 112409. Date of Electronic Publication: 2021 Nov 12.

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPAR γ , NF- κ B, and PI3K/Akt Signaling Pathways.

Autor: Yassin NYS; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt., AbouZid SF; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., El-Kalaawy AM; Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Ali TM; Department of Physiology, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Elesawy BH; Department of Pathology, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Ahmed OM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.

Publikováno v: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Sep 30; Vol. 2021, pp. 7665169. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).