Exploration of cytotoxicity of iodoquinazoline derivatives as inhibitors of both VEGFR-2 and EGFR ^T790M : Molecular docking, ADMET, design, and syntheses.

Autor: Alsulaimany M; Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina, Saudi Arabia., El-Hddad SSA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya., Akrim ZSM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Omar Almukhtar University Al-Bayda, Libya., Aljohani AKB; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia., Almohaywi B; Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Alatawi OM; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia., Almadani SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina, Saudi Arabia., Alharbi HY; Department of Chemistry, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., Aljohani MS; Department of Chemistry, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., Miski SF; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina, Saudi Arabia., Alghamdi R; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia., El-Adl K; Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Nov; Vol. 357 (11), pp. e2400389. Date of Electronic Publication: 2024 Aug 01.

Iodoquinazoline-derived VEGFR-2 and EGFR ^T790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations.

Autor: Mohamed AA; Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St, Dokki, Giza, A. R., Egypt., El-Hddad SSA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya., Aljohani AKB; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia., Khedr F; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt., Alatawi OM; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 47512, Saudi Arabia., Keshek DE; Department of Biology, Jumum College University, Umm Al-Qura University, P.O Box7388, Makkah 21955, Sudia Arabia; Agriculture Genetic Engineering Research Institute (AGERI), Agriculture Research Centre, Giza, Egypt., Ahmed S; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Alsulaimany M; Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia., Almadani SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia., El-Adl K; Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt. Electronic address: eladlkhaled74@yahoo.com., Hanafy NS; Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Feb; Vol. 143, pp. 107062. Date of Electronic Publication: 2023 Dec 25.

Design, synthesis, and docking of novel thiazolidine-2,4-dione multitarget scaffold as new approach for cancer treatment.

Autor: Hanafy NS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt., Aziz NAAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt., El-Hddad SSA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Dawood AF; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Mohamady S; Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt., El-Adl K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Ahmed S; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 Jul; Vol. 356 (7), pp. e2300137. Date of Electronic Publication: 2023 May 05.

Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.

Autor: El-Adl K; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, El-Salam City, Cairo, Egypt., Sakr H; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt., El-Hddad SSA; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt., El-Helby AA; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt., Nasser M; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt., Abulkhair HS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jul; Vol. 354 (7), pp. e2000491. Date of Electronic Publication: 2021 Mar 31.

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme.

Autor: El-Adl K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt. Electronic address: eladlkhaled74@azhar.edu.eg., El-Helby AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Sakr H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Eissa IH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., El-Hddad SSA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., M I A Shoman F; MD in Clinical Pathology, Blood Bank Specialist, Blood Bank Directorate Manager, Ministry of Health, Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Sep; Vol. 102, pp. 104059. Date of Electronic Publication: 2020 Jun 30.