In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.

Autor: Edward Yepes, Rubén E Varela-M, Julio López-Abán, El Habib Dakir, Faustino Mollinedo, Antonio Muro

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109431 (2014)

BACKGROUND: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schisto

Externí odkaz: https://doaj.org/article/ad70c884f3884ea0bf45b4487c04ea36

The anti-psychotic drug Pimozide is a Novel chemotherapeutic for Breast Cancer

Autor: Richard Morgan, Stephen Lloyd, El-Habib Dakir, Kirtiman Srivastava, Andriana Margariti, Stephane R. Gross, Cian M. McCrudden, Mohamed El-Tanani, Philip S. Rudland, Adam Pickard, Shu-Dong Zhang

Publikováno v: Oncotarget
Dakir, E-H, Pickard, A, Srivastava, K, McCrudden, C M, Gross, S R, Lloyd, S, Zhang, S-D, Margariti, A, Morgan, R, Rudland, P S & El-Tanani, M 2018, ' The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer ', Oncotarget, vol. 9, no. 79, pp. 34889-34910 . https://doi.org/10.18632/oncotarget.26175

Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to suppress cell growth of breast cancer cells in vitro. In this study we further explore the inhibitory effects of this molecule in cancer cells. We found that Pimo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4a5fa22ad94595e78f0bcd725b3ec7
https://publications.aston.ac.uk/id/eprint/37717/1/26175_1013860_6_PB.pdf

Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum

Autor: El Habib Dakir, Faustino Mollinedo, Rosalba I. Fonteriz, Javier Alvarez, Marcia Matos-da-Silva, Consuelo Gajate

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncogene

Pancreatic cancer remains as one of the most deadly cancers, and responds poorly to current therapies. The prognosis is extremely poor, with a 5-year survival of less than 5%. Therefore, search for new effective therapeutic drugs is of pivotal need a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33801d6dc918a420fe9003553e2e3bf
https://doi.org/10.1038/onc.2011.446

Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium

Autor: El Habib Dakir, R. Ilona Linnoila, Francesco J. DeMayo, Xu Naizhen, Sandra Jensen-Taubman, Xiao-Yang Wang

Publikováno v: Laboratory Investigation. 87:527-539

The basic helix-loop-helix protein achaete-scute homolog-1 (ASH1) is involved in lung neuroendocrine (NE) differentiation and tumor promotion in SV40 transgenic mice. Constitutive expression of human ASH-1 (hASH1) in mouse lung results in hyperplasia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a808b09aa6211b7f12590ebcb03bda
https://doi.org/10.1038/labinvest.3700552

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Autor: Mohamed El-Tanani, Bethany Raynor, Richard Morgan, El-Habib Dakir

Publikováno v: Cancers, Vol 8, Iss 3, p 35 (2016)
Cancers

Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3b04c4760edafccfa32bbb4d897fb0
https://doi.org/10.3390/cancers8030035