Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity.

Autor: Abdel-Rahman AA; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt. Adel.Nassar@science.menofia.edu.eg., El-Bayaa MN; Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia., Sobhy A; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., El-Ganzoury EM; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., Nossier ES; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.; The National Committee of Drugs, Academy of Scientific Research and Technology, Cairo, 11516, Egypt., Awad HM; Tanning Materials and Leather Technology Department, National Research Centre, Dokki, Giza, 12622, Egypt., El-Sayed WA; Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 23; Vol. 14 (1), pp. 24980. Date of Electronic Publication: 2024 Oct 23.