An overview of RAF kinases and their inhibitors (2019-2023).

Autor: Hashem O; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Shahin AI; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Al Hindawi MA; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Fageeri MF; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Al-Sbbagh SA; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Tarazi H; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., El-Gamal MI; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: drmelgamal2002@gmail.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116631. Date of Electronic Publication: 2024 Jun 27.

Next generation imidazothiazole and imidazooxazole derivatives as potential drugs against brain-eating amoebae.

Autor: Akbar N; Research Institute of Medical & Health Sciences, University of Sharjah, Sharjah, 27272, UAE., Siddiqui R; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University Edinburgh, Edinburgh, EH14 4AS,, UK.; Microbiota Research Center, Istinye University, Istanbul, 34010, Turkey., El-Gamal MI; Research Institute of Medical & Health Sciences, University of Sharjah, Sharjah, 27272, UAE.; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, 27272, UAE., Khan NA; Microbiota Research Center, Istinye University, Istanbul, 34010, Turkey. naveed5438@gmail.com., Zaraei SO; Research Institute of Medical & Health Sciences, University of Sharjah, Sharjah, 27272, UAE., Saeed BQ; Research Institute of Medical & Health Sciences, University of Sharjah, Sharjah, 27272, UAE.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, UAE., Alharbi AM; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia., Dash NR; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, UAE.

Publikováno v: Parasitology research [Parasitol Res] 2024 Jun 12; Vol. 123 (6), pp. 241. Date of Electronic Publication: 2024 Jun 12.

Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents.

Autor: Zaraei SO; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates., Dohle W; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom., Anbar HS; Department of Pharmaceutical Sciences, Dubai Pharmacy College for Girls, Dubai 19099, United Arab Emirates., El-Gamal R; Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Leblond B; Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom., Foster PA; Institute of Metabolism and Systems Research, 2(nd) Floor IBR Tower, University of Birmingham, Birmingham B15 2TT, United Kingdom; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, United Kingdom., Al-Tel TH; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates., Potter BVL; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom; Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom. Electronic address: barry.potter@pharm.ox.ac.uk., El-Gamal MI; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: drmelgamal2002@gmail.com.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Mar 01; Vol. 101, pp. 117645. Date of Electronic Publication: 2024 Feb 16.

Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.

Autor: Mersal KI; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, 12055, Egypt; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea., Abdel-Maksoud MS; Medicinal & Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre NRC (ID: 60014618), Dokki, Giza, 12622, Egypt., Ali EMH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, 12055, Egypt; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 West Stadium Avenue, West Lafayette, IN, 47907, USA., Ammar UM; School of Applied Sciences, Edinburgh Napier University, Sighthill Campus, 9 Sighthill Court, Edinburgh, EH11 4BN, United Kingdom., Zaraei SO; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Haque MM; Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA., Das T; Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA., Hassan NF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, 12055, Egypt., Kim EE; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 02792, South Korea., Lee JS; Department of Pharmacology, College of Medicine, Korea University, Seoul, 02841, South Korea., Park H; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, USA., Lee KH; Center for Advanced Biomolecular Recognition, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea., El-Gamal MI; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Kim HK; Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, 54907, Republic of Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, 54907, Republic of Korea. Electronic address: hkkim717@jbnu.ac.kr., Ibrahim TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Oh CH; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea. Electronic address: choh@kist.re.kr.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115779. Date of Electronic Publication: 2023 Sep 15.

The latest perspectives of small molecules FMS kinase inhibitors.

Autor: Alkubaisi BO; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Aljobowry R; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Ali SM; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Sultan S; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates., Zaraei SO; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Ravi A; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates., Al-Tel TH; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates. Electronic address: taltal@sharjah.ac.ae., El-Gamal MI; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: malgamal@sharjah.ac.ae.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115796. Date of Electronic Publication: 2023 Sep 07.