Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme-1/cyclooxygenase-2 inhibitors: Design, synthesis, anti-hypertensive, anti-fibrotic, and anti-inflammatory.

Autor: Fadaly WAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Elshaier YAMM; Organic & Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt., Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt., El-Bahrawy AH; Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt., Abdellatif KRA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia., Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Publikováno v: Drug development research [Drug Dev Res] 2024 Jun; Vol. 85 (4), pp. e22217.

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Mostafa YA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abdelrahman MH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., Trembleau L; School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, UK., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Aug 16; Vol. 15 (8). Date of Electronic Publication: 2022 Aug 16.

Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.

Autor: Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Omar ZMM; Department of Pharmacology, College of Medicine, Al-Azhar University, Assiut, Egypt., Rashwan EK; Department of Physiology, College of Medicine, Al-Azhar University, Assiut, Egypt., Abdel-Wahab BA; Department of Pharmacology, School of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Pharmacology, Assiut University, Assiut, Egypt., Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Publikováno v: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 May; Vol. 35 (5), pp. e22738. Date of Electronic Publication: 2021 Feb 01.

Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways.

Autor: Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt., El-Bahrawy AH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt., Taha HH; Department of Biochemistry, Faculty of Pharmacy, Al Azhar University, Assiut, 71524, Egypt., Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Electronic address: Faresali@azhar.edu.eg.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2020 Apr 15; Vol. 873, pp. 173008. Date of Electronic Publication: 2020 Feb 09.

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.

Autor: Ghonim MA; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. mghoni@lsuhsc.edu.; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. mghoni@lsuhsc.edu., Pyakurel K; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. kpyaku@lsuhsc.edu., Ibba SV; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. sibba@lsuhsc.edu., Al-Khami AA; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. aalkh@lsuhsc.edu.; Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt. aalkh@lsuhsc.edu., Wang J; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. jwang4@lsuhsc.edu., Rodriguez P; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. prodri1@lsuhsc.edu., Rady HF; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hrady@lsuhsc.edu., El-Bahrawy AH; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. alipharma2006@yahoo.com., Lammi MR; Pulmonary and Critical Care Section, School of Medicine, Louisiana State University, New Orleans, LA, USA. mlammi@lsuhsc.edu., Mansy MS; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. moselhysalah@gmail.com., Al-Ghareeb K; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. kamelalghareeb2000@gmail.com., Ramsay A; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. aramsay@lsuhsc.edu., Ochoa A; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. aochoa@lsuhsc.edu., Naura AS; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. anaura@pu.ac.in.; Department of Biochemistry, Panjab University, Chandigarh, India. anaura@pu.ac.in., Boulares AH; The Stanley Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA, 70112, USA. hboulr@lsuhsc.edu.

Publikováno v: Journal of translational medicine [J Transl Med] 2015 Jul 14; Vol. 13, pp. 225. Date of Electronic Publication: 2015 Jul 14.