Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies.

Autor: Hassan NW; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt., Sabt A; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt., El-Attar MAZ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt., Ora M; Department of Chemistry, University of Turku, 20500, Turku, Finland., Bekhit AEA; Department of Food Science, University of Otago, Dunedin, 9054, New Zealand., Amagase K; Laboratory of Pharmacology & Pharmacotherapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan., Bekhit AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt; Pharmacy Program, Allied Health Department, College of Health Sciences, University of Bahrain, P.O. Box 32038, Bahrain., Belal ASF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address: ahmed.belal@alexu.edu.eg., Elzahhar PA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address: perihan.elzahhar@alexu.edu.eg.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 May 05; Vol. 253, pp. 115333. Date of Electronic Publication: 2023 Apr 05.

Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Autor: El-Attar MAZ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Elbayaa RY; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, 21311, Egypt. Electronic address: rasha.bayaa@pua.edu.eg., Shaaban OG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, 21311, Egypt., Habib NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Abdel Wahab AE; Genetic Engineering and Biotechnology Research Institute (GEBRI), The City for Scientific Research and Technology Application, Borg El-Arab, Alexandria, Egypt., Abdelwahab IA; Department of Microbiology and Immunology, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, 21311, Egypt., El-Hawash SAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2018 Feb; Vol. 76, pp. 437-448. Date of Electronic Publication: 2017 Dec 05.

New protocols for the synthesis of 5-amino-7-(4-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate esters using an efficient additive.

Autor: KHALIGH, Nader GHAFFARI¹ ngkhaligh@um.edu.my, MIHANKHAH, Taraneh², TITINCHI, Salam³, SHAHNAVAZ, Zohreh¹, JOHAN, Mohd RAFIE¹

Publikováno v: Turkish Journal of Chemistry. 2020, Vol. 44 Issue 4, Following p1100-1109. 12p.

In-silico identification and exploration of small molecule coumarin-1,2,3-triazole hybrids as potential EGFR inhibitors for targeting lung cancer.

Autor: Kumar S; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India., Ali I; Department of Biosciences, COMSATS University Islamabad, Islamabad Campus, Islamabad, 45550, Pakistan., Abbas F; Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, People's Republic of China., Shafiq F; Department of Chemistry, University of Agriculture, Faisalabad, 38040, Pakistan., Yadav AK; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India., Ghate MD; School of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujarat, 382007, India., Kumar D; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India. guptadeepak002@gmail.com.

Publikováno v: Molecular diversity [Mol Divers] 2024 Mar 12. Date of Electronic Publication: 2024 Mar 12.

Synthesis of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines as antimicrobial agents with potential inhibition of DHPS enzyme.

Autor: Z El-Attar, Maryam A, Elbayaa, Rasha Y, Shaaban, Omaima G, Habib, Nargues S, Abdel Wahab, Abeer E, Abdelwahab, Ibrahim A, M El-Hawash, Soad A

Publikováno v: Future Medicinal Chemistry; Sep2018, Vol. 10 Issue 18, p2155-2175, 21p