Epithelial-mesenchymal transition and membrane microparticles: Potential implications for bronchiolitis obliterans syndrome after lung transplantation

Autor: Renaud-Picard, Benjamin, Vallière, Kevin, Toussaint, Justine, Kreutter, Guillaume, El-Habhab, Ali, Kassem, Mohamad, El-Ghazouani, Fatiha, Olland, Anne, Hirschi, Sandrine, Porzio, Michele, Chenard, Marie-Pierrette, Toti, Florence, Kessler, Laurence, Kessler, Romain

Publikováno v: In Transplant Immunology April 2020 59

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Data from Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia

Autor: Vanessa Desplat, Jean-Max Pasquet, Isabelle Vigon, Arnaud Pigneux, Thibaut Leguay, Solene Fernandez, Delphine Martineau, Audrey Bidet, Olivier Mansier, Layal Massara, Ali El-habhab, Amélie V. Guitart, Arnaud Villacreces, Pierre-Yves Dumas

Purpose:AXL has been shown to play a pivotal role in the selective response of FLT3-ITD acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within the bone marrow microenvironment.Experimental Design:Herein, we c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fb13b57418c367a8a9d681c35d338d
https://doi.org/10.1158/1078-0432.c.6530471.v1

In Vitro Impact of Pro-Senescent Endothelial Microvesicles on Isolated Pancreatic Rat Islets Function

Autor: Valérie B. Schini-Kerth, Guillaume Kreutter, Ali El Habhab, Florence Toti, Lamia Amoura, Fatiha Zobairi, Laurence Kessler, Noura Sbat, Mohamad Kassem, Malak Abbas, Philippe Baltzinger

Publikováno v: Transplantation Proceedings. 53:1736-1743

Ischemia-driven islet isolation procedure is one of the limiting causes of pancreatic islet transplantation. Ischemia-reperfusion process is associated with endothelium dysfunction and the release of pro-senescent microvesicles. We investigated wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d4a66217eed8a40f35ddb05b003204
https://doi.org/10.1016/j.transproceed.2021.02.023

Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells

Autor: Marine Dupont, Mathilde Huart, Claire Lauvinerie, Audrey Bidet, Amélie Valérie Guitart, Arnaud Villacreces, Isabelle Vigon, Vanessa Desplat, Ali El Habhab, Arnaud Pigneux, Zoran Ivanovic, Philippe Brunet De la Grange, Pierre-Yves Dumas, Jean-Max Pasquet

Publikováno v: Cancers
Cancers, Vol 14, Iss 453, p 453 (2022)
Cancers; Volume 14; Issue 2; Pages: 453
Cancers, 2022, 14 (2), pp.453. ⟨10.3390/cancers14020453⟩

Simple Summary One of the most frequent molecular anomalies in acute myeloid leukemia (AML) is the mutation of the fms-like receptor tyrosine kinase 3 through internal tandem duplications, giving rise to a constitutive proliferative signaling. Even t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9d3730986691e7846176276cdc4e5d
https://pubmed.ncbi.nlm.nih.gov/35053612