Zobrazeno 1 - 10
of 24
pro vyhledávání: '"El Habib Hani"'
Autor:
Violeta Mitutsova, Wendy Wai Yeng Yeo, Romain Davaze, Celine Franckhauser, El-Habib Hani, Syahril Abdullah, Patrice Mollard, Marie Schaeffer, Anne Fernandez, Ned J. C. Lamb
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-14 (2017)
Abstract Background Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the potential of a population
Externí odkaz:
https://doaj.org/article/5497ce5711d24500becfb3a0f2424c51
Publikováno v:
Biochimie
Biochimie, Elsevier, 2016, 125, pp.32-41. ⟨10.1016/j.biochi.2016.02.008⟩
Biochimie, Elsevier, 2016, 125, pp.32-41. ⟨10.1016/j.biochi.2016.02.008⟩
International audience; Specificity of the cAMP-dependent protein kinase (PKA) pathway relies on an extremely sophisticated compartmentalization mechanism of the kinase within a given cell, based on high-affinity binding of PKA tetramer pools to diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f010565c84e73075f52921ff913552
https://hal.archives-ouvertes.fr/hal-01356672
https://hal.archives-ouvertes.fr/hal-01356672
Autor:
Omar Faruque, El Habib Hani, Christine Longuet, Safia Costes, Dominique Bataille, Christophe Broca, Stéphane Dalle
Publikováno v:
Annals of the New York Academy of Sciences. 1030:230-242
Long-term hyperglycemia, a major characteristic of the diabetic state, contributes to the deterioration of the beta cell function, a concept known as beta cell glucotoxicity. We used the MIN6 beta cell line and isolated rat islets to clarify the sign
Autor:
Safia Costes, Ghislaine Fontés, Stéphane Dalle, El Habib Hani, Christine Longuet, Dominique Bataille
Publikováno v:
Annales d'Endocrinologie. 65:24-27
Autor:
Violeta Stanojevic, Philippe Froguel, El Habib Hani, Doris A. Stoffers, Jean-Claude Chèvre, Emmanuelle Durand, Christian Dina, Joel F. Habener
Publikováno v:
Journal of Clinical Investigation. 104:R41-R48
Type 2 diabetes mellitus is a common disabling disease with onset in middle-aged individuals, caused by an imbalance between insulin production and action. Genetic studies point to major genetic components, but, with the exception of maturity-onset d
Autor:
M. A. Permutt, El Habib Hani, Emmanuelle Durand, H. Inoue, Philippe Froguel, Philippe Boutin, Gilberto Velho
Publikováno v:
Diabetologia. 41:1511-1515
The K+ inwardly rectifier channel (KIR) is one of the two sub-units of the pancreatic islet ATP-sensitive potassium channel complex (I(KATP)), which has a key role in glucose-stimulated insulin secretion and thus is a potential candidate for a geneti
Autor:
Anne Philippi, Florence Demenais, Philippe Froguel, Jacques S. Beckmann, Habib Zouali, El Habib Hani, Nathalie Vionnet
Publikováno v:
Human Molecular Genetics. 6:1401-1408
Several candidate genes for non-insulin-dependent diabetes mellitus (NIDDM) map on chromosome 20, including the phosphoenolpyruvate carboxykinase gene (PCK1) and one of the maturity onset diabetes of the young genes (MODY1). Thus, we have investigate
Autor:
M. A. Permutt, Markus Stoffel, Y. Tanizawa, Jörg Hager, Anne Philippi, M. Varret, Ken C. Chiu, Philippe Passa, Florence Demenais, Philippe Froguel, Beate Glaser, El Habib Hani, Nathalie Vionnet, Suzanne Lesage
Publikováno v:
ResearcherID
As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein–coupled inwardly rectifying potassium channels expre
Autor:
Jörg Hager, M. A. Permutt, Philippe Froguel, H. Inoue, Anne Philippi, Karine Clément, Florence Demenais, Christian Dina, El Habib Hani, Arnaud Basdevant, Michael North, B. Guy-Grand, G. Velho, Nathalie Vionnet
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
The sulfonylurea receptor (SUR) is a key component in glucose-stimulated insulin secretion. Obesity and NIDDM are frequently associated and share some metabolic abnormalities, suggesting that they might also share some susceptibility genes. Thus, the
Autor:
Bernard Thorens, Dorra Cherif, El Habib Hani, Nathalie Vionnet, Philippe Froguel, Sandrine Gremlich, Andrée Porret
Publikováno v:
Diabetes. 44:1202-1208
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted by the endocrine K-cells from the duodenum that stimulates glucose-induced insulin secretion. Here, we present the molecular characterization of the human pancreatic islet GIP r