Zobrazeno 1 - 10
of 76
pro vyhledávání: '"El Bachir, Affar"'
Autor:
Yi Zhang, Guojia Xie, Ji-Eun Lee, Mohamad Zandian, Deepthi Sudarshan, Benjamin Estavoyer, Caroline Benz, Tiina Viita, Golareh Asgaritarghi, Catherine Lachance, Clémence Messmer, Leandro Simonetti, Vikrant Kumar Sinha, Jean-Philippe Lambert, Yu-Wen Chen, Shu-Ping Wang, Ylva Ivarsson, El Bachir Affar, Jacques Côté, Kai Ge, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers. Here, we report a novel functi
Externí odkaz:
https://doaj.org/article/638cdaae4793463e86fdbad0e7036a1b
Autor:
Stefania Bottardi, Taylorjade Layne, Ailyn C. Ramòn, Norreen Quansah, Hugo Wurtele, El Bachir Affar, Eric Milot
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inflammation control is critical during the innate immune response. Such response is triggered by the detection of molecules originating from pathogens or damaged host cells by pattern-recognition receptors (PRRs). PRRs subsequently initiate intra-ce
Externí odkaz:
https://doaj.org/article/32d3186ae4374b99a2993f199c97786d
Autor:
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suit
Externí odkaz:
https://doaj.org/article/43e12a5532544c0686ece219c67a0571
Autor:
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clémence Messmer, Mila Gushul-Leclaire, Romain Villot, Maxime Uriarte, Karine Boulay, Sari Hlayhel, Bassel Farhat, Eric Milot, Frédérick A. Mallette, Salima Daou, El Bachir Affar
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106276- (2023)
Summary: Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodege
Externí odkaz:
https://doaj.org/article/8268603610614df7a8f26515e242e596
Autor:
Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed, Clémence Messmer, Nazar Mashtalir, Haithem Barbour, Louis Masclef, Marion Voide, Claire Viallard, Salima Daou, Djaileb Abdelhadi, Daryl Ronato, Mohammadjavad Paydar, Anaïs Darracq, Karine Boulay, Nicolas Desjardins-Lecavalier, Przemyslaw Sapieha, Jean-Yves Masson, Mikhail Sergeev, Benjamin H. Kwok, Laura Hulea, Frédérick A. Mallette, Eric Milot, Bruno Larrivée, Hugo Wurtele, El Bachir Affar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient reple
Externí odkaz:
https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Histone H2A monoubiquitination on lysine 119 in vertebrate and lysine 118 in Drosophila (H2Aub) is an epigenomic mark usually associated with gene repression by Polycomb group factors. Here the authors review the current knowledge on the deposition a
Externí odkaz:
https://doaj.org/article/bd9ef5e9d7494f88a04d126380621916
Autor:
Oumaima Ahmed, Malik Affar, Louis Masclef, Mohamed Echbicheb, Mila Gushul-Leclaire, Benjamin Estavoyer, David J. Vocadlo, El Bachir Affar
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101108- (2022)
Summary: Detection of protein O-GlcNAcylation could be challenging. By using the host-cell factor 1 (HCF-1), a known O-GlcNAcylated protein, we immunoprecipitated HCF-1 from transfected HEK293T cells or endogenous HCF-1 from HeLa cells to detect its
Externí odkaz:
https://doaj.org/article/75a5275dc20f46a7bb74b42e977d9fb1
Autor:
Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that B
Externí odkaz:
https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a6
Autor:
Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008463 (2019)
Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is charact
Externí odkaz:
https://doaj.org/article/f994d6816a354d76ae7c455bbb3ae1c1
Autor:
Loïc Binan, François Bélanger, Maxime Uriarte, Jean François Lemay, Jean Christophe Pelletier De Koninck, Joannie Roy, El Bachir Affar, Elliot Drobetsky, Hugo Wurtele, Santiago Costantino
Publikováno v:
eLife, Vol 8 (2019)
The ability to isolate rare live cells within a heterogeneous population based solely on visual criteria remains technically challenging, due largely to limitations imposed by existing sorting technologies. Here, we present a new method that permits
Externí odkaz:
https://doaj.org/article/537e4cd9b73c45eb9749faa532d5e2a4