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The Hypoxia-Inducible MicroRNA Cluster miR-199a similar to 214 Targets Myocardial PPAR delta and Impairs Mitochondrial Fatty Acid Oxidation

Autor: El Azzouzi, H., Leptidis, S., Dirkx, E., Hoeks, J., van Bree, B., van de Brand, K, McClellan, E.A., Poels, E., Sluimer, J.C., van den Hoogenhof, M.M., Armand, A.S., Yin, X., Langley, S., Bourajjaj, M., Olieslagers, S., Krishnan, J., Vooijs, M., Kurihara, H., Stubbs, A., Pinto, Y.M., Krek, W., Mayr, M., da Costa Martins, P.A., Schrauwen, P., De Windt, L.J.

Publikováno v: Cell Metabolism, 18(3), 341-354. Cell Press

Peroxisomeproliferator-activatedreceptor delta(PPAR delta) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f36d2c2a78d72613cf57b39d949fc63b
https://pure.eur.nl/en/publications/b525112a-986a-4fcb-ab86-a6f505e6dfc7

Peroxisome proliferators-activated receptor (PPAR) regulation in cardiac metabolism and disease

Autor: el Azzouzi, H.

Peroxisome proliferators-activated receptors (PPARs) are members of the nuclear receptor family of ligand activated transcription factors and consist of the three isoforms, PPAR, PPAR/ and PPAR. Considerable evidence has established the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::afd3ef388e0255b2e13ef3affec6ef63
https://dspace.library.uu.nl/handle/1874/33347

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

Autor: da Costa Martins, P.A., Salic, K., Gladka, M., Armand, A.S., Leptidis, S., el Azzouzi, H., Hansen, A., Coenen-de Roo, C.J., Bierhuizen, M.F.A., van der Nagel, R., van Kuik, J., de Weger, R.A., de Bruin, A., Condorelli, G., Arbones, M.L., Eschenhagen, T., de Windt, L.J., Tissue Repair, Dep Pathobiologie

Publikováno v: Nature Cell Biology, 12(12), 1220-1227. Nature Publishing Group
Nature Cell Biology, 12(12), 1220-U231. Nature Publishing Group
Nature Cell Biology, 12, 1220

MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides in length1,2. Increasing evidence implicates miRs in myocardial disease processes3,4,5,6,7,8,9,10,11. Here we show that miR-199b is a direct calcineurin/NFAT tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3359952e418839f6317350a89e2b426d
https://hdl.handle.net/1874/191164

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