Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors.

Autor: Abo-Elmagd MI; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboutabl ME; Medicinal and Pharmaceutical Chemistry Department, Pharmacology Group, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Amin KM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., El-Azzouny AA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboul-Enein MN; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: mnaboulenein@yahoo.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107577. Date of Electronic Publication: 2024 Jun 18.

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance.

Autor: Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: rashahassan_pharma@yahoo.ca., Abd El-Maksoud MS; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt., El-Azzouny AA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboul-Enein MN; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: mnaboulenein@yahoo.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 15; Vol. 262, pp. 115867. Date of Electronic Publication: 2023 Oct 11.

Design and synthesis of novel parabanic acid derivatives as anticonvulsants.

Autor: Aboutabl ME; Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., El-Azzouny AA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboul-Enein MN; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: mnaboulenein@yahoo.com., Abd-Allah WH; Pharmaceutical Chemistry Department, College of Pharmaceutical Science and Drug Manufacturing, Misr University for Science & Technology, P.O. 77, 6th of October City, Giza, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Jan; Vol. 94, pp. 103473. Date of Electronic Publication: 2019 Nov 25.

Synthesis, molecular modeling studies, and anticonvulsant evaluation of novel 1-((2-hydroxyethyl)(aryl)amino)-N-substituted cycloalkanecarboxamides and their acetate esters.

Autor: Aboul-Enein MN; Department of Medicinal and Pharmaceutical Chemistry, Medicinal Chemistry Group, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt., El-Azzouny AA; Department of Medicinal and Pharmaceutical Chemistry, Medicinal Chemistry Group, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt., Amin KM; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt., Aboutabl ME; Department of Medicinal and Pharmaceutical Chemistry, Pharmacology Group, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt., Abo-Elmagd MI; Department of Medicinal and Pharmaceutical Chemistry, Medicinal Chemistry Group, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2018 Dec; Vol. 351 (12), pp. e1800269. Date of Electronic Publication: 2018 Nov 21.

Enantioseparation of Substituted 1, 3-Diazaspiro [4.5]Decan-4-Ones: HPLC Comparative Study on Different Polysaccharide Type Chiral Stationary Phases.

Autor: Aboul-Enein HY; Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 12622 Dokki, Giza 12622, Egypt., Aboul-Enein MN; Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 12622 Dokki, Giza 12622, Egypt., El-Azzouny AA; Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 12622 Dokki, Giza 12622, Egypt., Saleh OA; Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 12622 Dokki, Giza 12622, Egypt., Hassan RM; Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 12622 Dokki, Giza 12622, Egypt., Amin KM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Publikováno v: Journal of chromatographic science [J Chromatogr Sci] 2018 Feb 01; Vol. 56 (2), pp. 160-165.