Zobrazeno 1 - 10
of 382
pro vyhledávání: '"El‐Tanani, Mohamed"'
Autor:
Haggag, Y., Abu Ras, Bayan, El-Tanani, Yahia, Tambuwala, M.M., McCarron, P., Isreb, Mohammad, El-Tanani, Mohamed
Yes
Multidrug resistance (MDR) limits the beneficial outcomes of conventional breast cancer chemotherapy. Ras-related nuclear protein (Ran-GTP) plays a key role in these resistance mechanisms, assisting cancer cells to repair damage to DNA. Here
Multidrug resistance (MDR) limits the beneficial outcomes of conventional breast cancer chemotherapy. Ras-related nuclear protein (Ran-GTP) plays a key role in these resistance mechanisms, assisting cancer cells to repair damage to DNA. Here
Externí odkaz:
http://hdl.handle.net/10454/18020
Autor:
Haggag, Y.A., Matchett, K.B., Falconer, Robert A., Isreb, Mohammad, Jones, Jason, Faheem, A., McCarron, P., El-Tanani, Mohamed
Yes
The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer t
The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer t
Externí odkaz:
http://hdl.handle.net/10454/17484
Autor:
Haggag, Y.A., Matchett, K.B., Dakir, El-Habib, Buchanan, P., Osman, M.A., Elgizawy, S.A., El-Tanani, Mohamed, Faheem, A.M., McCarron, P.A.
Yes
Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which preven
Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which preven
Externí odkaz:
http://hdl.handle.net/10454/11435
Autor:
Morgan, Richard, Ankrah, R., El-Tanani, S., Patterson, Laurence H., Loadman, Paul, Rudland, P.S., El-Tanani, Mohamed
Wnt signaling normally functions in cell determination and proliferation and is essential for embryonic development. It does this by regulating target genes through a tightly regulated but complex signaling cascade. Overexpression of these genes due
Externí odkaz:
http://hdl.handle.net/10454/12056
Autor:
Morgan, Richard, El-Tanani, Mohamed
Yes
Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isola
Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isola
Externí odkaz:
http://hdl.handle.net/10454/9895
Autor:
Haggag, Y.A., Abdel-Wahab, Y., Ojo, O., Osman, M.A., El-Gizawy, S., El-Tanani, Mohamed, Faheem, A., McCarron, P.A.
Yes
The aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation f
The aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation f
Externí odkaz:
http://hdl.handle.net/10454/8405
Autor:
Wong, J.P.C., Wei, R., Lyu, P., Tong, O.L.H., Zhang, S.D., Wen, Q., Yuen, H.F., El-Tanani, Mohamed, Kwok, H.F.
Yes
Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive. In this study, we have shown that expression of OPN was significantly higher in bladder canc
Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive. In this study, we have shown that expression of OPN was significantly higher in bladder canc
Externí odkaz:
http://hdl.handle.net/10454/15341
Autor:
Alharbi, R.A., Pandha, H.S., Simpson, G.R., Pettengell, R., Poterlowicz, Krzysztof, Thompson, A., Harrington, K.J., El-Tanani, Mohamed, Morgan, Richard
Yes
The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a
The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a
Externí odkaz:
http://hdl.handle.net/10454/13040
Autor:
Chan, K.K., Matchett, K.B., Coulter, J.A., Yuen, H-F., McCrudden, C.M., Zhang, S-D., Irwin, G.W., Davidson, M.A., Rülicke, T., Schober, S., Hengst, L., Jaekel, H., Platt-Higgins, A., Rudland, P.S., Mills, K.I., Maxwell, P., El-Tanani, Mohamed, Lappin, T.R.
Yes
Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with recombinant erythropoietin (EPO) to stimulate red blood cell production. Clinical studie
Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with recombinant erythropoietin (EPO) to stimulate red blood cell production. Clinical studie
Externí odkaz:
http://hdl.handle.net/10454/11644
Yes
The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide ra
The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide ra
Externí odkaz:
http://hdl.handle.net/10454/11620