Výsledky vyhledávání - "Elżbieta Wątor"

Akademický článek

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Autor: Elżbieta Wątor, Piotr Wilk, Artur Biela, Michał Rawski, Krzysztof M. Zak, Wieland Steinchen, Gert Bange, Sebastian Glatt, Przemysław Grudnik

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

eIF5A is the only protein known to contain hypusine. Here, the authors present the cryoEM structure of the eIF5A-DHS complex and provide mechanistic insights to understand the deoxyhypusination reaction and hypusination-related neurodegeneration.

Externí odkaz: https://doaj.org/article/e4e3adc8dd2e42ca879034e54b682cda

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Akademický článek

Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing

Autor: Natália D. Linhares, Piotr Wilk, Elżbieta Wątor, Meire A. Tostes, Manfred S. Weiss, Sergio D. J. Pena

Publikováno v: Genetics and Molecular Biology, Vol 44, Iss 2 (2021)

Abstract Prolidase Deficiency (PD) is an autosomal recessive rare disorder caused by loss or reduction of prolidase enzymatic activity due to variants in the PEPD gene. PD clinical features vary among affected individuals: skin ulcerations, recurrent

Externí odkaz: https://doaj.org/article/095834c498af4c0997716394a8aa051c

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Akademický článek

Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum

Autor: Piotr Wilk, Katarzyna Kuśka, Elżbieta Wątor, Piotr H. Małecki, Klaudia Woś, Piotr Tokarz, Grzegorz Dubin, Przemysław Grudnik

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 24, p 9570 (2020)

Glycerol is an organic compound that can be utilized as an alternative source of carbon by various organisms. One of the ways to assimilate glycerol by the cell is the phosphorylative catabolic pathway in which its activation is catalyzed by glycerol

Externí odkaz: https://doaj.org/article/008c8d7ae44848528b82703fb700301f

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Akademický článek

Half Way to Hypusine—Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase

Autor: Elżbieta Wątor, Piotr Wilk, Przemysław Grudnik

Publikováno v: Biomolecules, Vol 10, Iss 4, p 522 (2020)

Deoxyhypusine synthase (DHS) is a transferase enabling the formation of deoxyhypusine, which is the first, rate-limiting step of a unique post-translational modification: hypusination. DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine

Externí odkaz: https://doaj.org/article/d37a50bdaa954703bcf64dafcc414325

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Akademický článek

Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1)

Autor: Krzysztof M. Zak, Magdalena Kalińska, Elżbieta Wątor, Katarzyna Kuśka, Rościsław Krutyhołowa, Grzegorz Dubin, Grzegorz M. Popowicz, Przemysław Grudnik

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 19, p 4821 (2019)

Glucose phosphorylating enzymes are crucial in the regulation of basic cellular processes, including metabolism and gene expression. Glucokinases and hexokinases provide a pool of phosphorylated glucose in an adenosine diphosphate (ADP)- and ATP-depe

Externí odkaz: https://doaj.org/article/bd596ffac00d4773afbf45c1807e58b7

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Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing

Autor: Piotr Wilk, Sérgio D.J. Pena, Elżbieta Wątor, Meire A. Tostes, Natália D. Linhares, Manfred S. Weiss

Publikováno v: Genetics and Molecular Biology v.44 n.2 2021
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Genetics and Molecular Biology, Volume: 44, Issue: 2, Article number: e20200393, Published: 19 APR 2021
Genetics and Molecular Biology, Vol 44, Iss 2 (2021)

Prolidase Deficiency (PD) is an autosomal recessive rare disorder caused by loss or reduction of prolidase enzymatic activity due to variants in the PEPD gene. PD clinical features vary among affected individuals: skin ulcerations, recurrent infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7de0873a195f0968aa3efc8bed4139
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000300105

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Structural characterization of glycerol kinase from the thermophilic fungus chaetomium thermophilum

Autor: Elżbieta Wątor, Piotr Wilk, Klaudia Woś, Piotr H. Malecki, Grzegorz Dubin, Piotr Tokarz, Przemyslaw Grudnik, Katarzyna Kuśka

Publikováno v: International Journal of Molecular Sciences, 21 (24)
International journal of molecular sciences 21(24), 9570-(2020). doi:10.3390/ijms21249570
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9570, p 9570 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed7376578a814a5391925c571c6d4a1
https://hdl.handle.net/20.500.11850/458842

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Prolidase - A protein with many faces

Autor: Piotr Wilk, Manfred S. Weiss, Elżbieta Wątor

Publikováno v: Biochimie. 183

Prolidase is a metal-dependent peptidase specialized in the cleavage of dipeptides containing proline or hydroxyproline on their C-termini. Prolidase homologues are found in all kingdoms of life. The importance of prolidase in human health is underli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0543d8505d6c4642841a68fc036d4fee
https://pubmed.ncbi.nlm.nih.gov/33045291

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