Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Elżbieta Brzezińska"'
Autor:
Karolina Wanat, Elżbieta Brzezińska
Publikováno v:
Membranes, Vol 13, Iss 7, p 623 (2023)
Blood–brain barrier (BBB) permeability is an essential phenomena when considering the treatment of neurological disorders as well as in the case of central nervous system (CNS) adverse effects caused by peripherally acting drugs. The presented work
Externí odkaz:
https://doaj.org/article/eb4450b45b844c1a816a23be807f0bb6
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1172 (2023)
Chromatographic retention data collected on immobilized keratin (KER) or immobilized artificial membrane (IAM) stationary phases were used to predict skin permeability coefficient (log Kp) and bioconcentration factor (log BCF) of structurally unrelat
Externí odkaz:
https://doaj.org/article/f8494ceed3b14c55bb23db8a5ce0db00
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 67 (2022)
Chromatographic retention factors (log kKERATIN) of 33 molecules were obtained on an immobilized keratin stationary phase by Turowski and Kaliszan (J. Pharm. Biomed. Anal. 15, 1997, 1325–1333). Their objective was to develop a novel stationary phas
Externí odkaz:
https://doaj.org/article/688d2bfe06d2455a9353027f1dde6534
Autor:
Karolina Wanat, Elżbieta Brzezińska
Publikováno v:
Molecules, Vol 27, Iss 11, p 3441 (2022)
Protein binding (PB) is indicated as the factor most severely limiting distribution in the organism, reducing the bioavailability of the drug, but also minimizing the penetration of xenobiotics into the fetus or the body of a breastfed child. Therefo
Externí odkaz:
https://doaj.org/article/30420fb7a9854877a40c3b4fe72fee39
Autor:
Anna W. Sobańska, Elżbieta Brzezińska
Publikováno v:
Molecules, Vol 27, Iss 6, p 1893 (2022)
Chromatographic retention factor log kIAM obtained from IAM HPLC chromatography with buffered aqueous mobile phases and calculated molecular descriptors (surface area—Sa; molar volume—VM; polar surface area—PSA; count of freely rotable bonds—
Externí odkaz:
https://doaj.org/article/7c9067f057334a4db7bc3345f0f6023b
Publikováno v:
Acta Innovations, Iss 27, Pp 53-60 (2018)
Synthetic food dyes (E102, E104, E110, E122, E124, E132, E133) were concentrated by solid phase extraction on aminopropyl modified silica with aqueous sodium hydroxide or selected amines as eluents. Ponceau 4R (E124) was used as the model dye in the
Externí odkaz:
https://doaj.org/article/88820512e70c46bcb4a441a564c6fb19
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 600 (2021)
The skin permeability of steroids, as investigated in this study, is important because some of these compounds are, or could, be used in preparations applied topically. Several models of skin permeability, involving thin layer chromatographic and cal
Externí odkaz:
https://doaj.org/article/b4d348e9aa0b4d038c03dba546f48b3b
Publikováno v:
Journal of Chemistry, Vol 2019 (2019)
One hundred ten compounds of diverse structures (actives and excipients used in pharmaceutical preparations) were studied by RP-18 HPLC with acetonitrile-pH 7.4 phosphate buffer 1 : 1 (v/v) as the mobile phase. The relationships between the BBB perme
Externí odkaz:
https://doaj.org/article/d593fd5a6afc4a5e8938d377d3146f0f
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 147 (2021)
Several chromatographic parameters (RM0 and S obtained from RP-18 TLC with methanol—pH 7.4 phosphate buffer mobile phases by extrapolation to zero concentration of methanol; Rf and RM obtained from RP-18 TLC with acetonitrile—pH 7.4 phosphate buf
Externí odkaz:
https://doaj.org/article/1644c9d416724cbaa56eba2ca38d2eb7
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 202 (2021)
Plasma protein binding is an important determinant of the pharmacokinetic properties of chemical compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatographic experiments.
Externí odkaz:
https://doaj.org/article/9a57f9150cbc402fbfaf850cea59af3e