Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eléonore W E Verweij"'
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1127 (2021)
The histamine H4 receptor (H4R) is a G protein-coupled receptor that is predominantly expressed on immune cells and considered to be an important drug target for various inflammatory disorders. Like most GPCRs, the H4R activates G proteins and recrui
Externí odkaz:
https://doaj.org/article/f6849197ba254907b2d06507d63556a3
Autor:
Eléonore W E Verweij, Henry F. Vischer, Rudi Prihandoko, Wimzy R Prabhata, Rob Leurs, Betty Al Araaj, Saskia Nijmeijer, Andrew B. Tobin
Publikováno v:
ACS Pharmacology and Translational Science, 3(2), 321-333. American Chemical Society
Verweij, E W E, Al Araaj, B, Prabhata, W R, Prihandoko, R, Nijmeijer, S, Tobin, A B, Leurs, R & Vischer, H F 2020, ' Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H 4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling ', ACS Pharmacology and Translational Science, vol. 3, no. 2, pp. 321-333 . https://doi.org/10.1021/acsptsci.0c00008
Verweij, E W E, Al Araaj, B, Prabhata, W R, Prihandoko, R, Nijmeijer, S, Tobin, A B, Leurs, R & Vischer, H F 2020, ' Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H 4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling ', ACS Pharmacology and Translational Science, vol. 3, no. 2, pp. 321-333 . https://doi.org/10.1021/acsptsci.0c00008
The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2 upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled receptor (GPCR) signaling by interacting with phosphorylated serine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe2187c2729b5ad1ccf20ea502ca06d
http://www.scopus.com/inward/record.url?scp=85088849349&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85088849349&partnerID=8YFLogxK
Autor:
Eléonore W. E. Verweij, Reggie Bosma, Meichun Gao, Jelle van den Bor, Betty Al Araaj, Sabrina M. de Munnik, Xiaoyuan Ma, Rob Leurs, Henry F. Vischer
Publikováno v:
Verweij, E W E, Bosma, R, Gao, M, van den Bor, J, Al Araaj, B, de Munnik, S M, Ma, X, Leurs, R & Vischer, H F 2022, ' BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H 1 Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins ', International Journal of Molecular Sciences, vol. 23, no. 6, 3184, pp. 1-17 . https://doi.org/10.3390/ijms23063184
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3184
International Journal of Molecular Sciences, 23(6):3184, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3184
International Journal of Molecular Sciences, 23(6):3184, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)
The histamine H1 receptor (H1R) is a G protein-coupled receptor (GPCR) and plays a key role in allergic reactions upon activation by histamine which is locally released from mast cells and basophils. Consequently, H1R is a well-established therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7de0207f611c3fe876753b4eab3d5f
https://research.vu.nl/en/publications/3cc316fb-d7af-416f-a7c7-28cc7ecf8312
https://research.vu.nl/en/publications/3cc316fb-d7af-416f-a7c7-28cc7ecf8312
Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H3 and H4 Receptors on Living Cells
Publikováno v:
Mocking, T A M, Verweij, E W E, Vischer, H F & Leurs, R 2018, ' Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H 3 and H 4 Receptors on Living Cells ', Molecular pharmacology, vol. 94, no. 6, pp. 1371-1381 . https://doi.org/10.1124/mol.118.113373
Molecular pharmacology, 94(6), 1371-1381. American Society for Pharmacology and Experimental Therapeutics
Molecular pharmacology, 94(6), 1371-1381. American Society for Pharmacology and Experimental Therapeutics
Receptor-binding affinity and ligand-receptor residence time are key parameters for the selection of drug candidates and are routinely determined using radioligand competition-binding assays. Recently, a novel bioluminescence resonance energy transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9be98a609a4e9d6a2536ed22acfc05
https://hdl.handle.net/1871.1/ab89aa38-fe7c-4856-8d8c-415e4051d9fc
https://hdl.handle.net/1871.1/ab89aa38-fe7c-4856-8d8c-415e4051d9fc
Publikováno v:
Molecular pharmacology. 94(6)
Receptor-binding affinity and ligand-receptor residence time are key parameters for the selection of drug candidates and are routinely determined using radioligand competition-binding assays. Recently, a novel bioluminescence resonance energy transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b4e26ec16f21b9052c36bc69311b25f
https://pubmed.ncbi.nlm.nih.gov/30249614
https://pubmed.ncbi.nlm.nih.gov/30249614
Autor:
Eléonore W E Verweij, Tamara A. M. Mocking, Daniel Da Costa Pereira, Maikel Wijtmans, Iwan J. P. de Esch, Gerda C M Vreeker, Henry F. Vischer, Albert J. Kooistra, Rob Leurs, Albertus H. de Boer, Martine J. Smit, Chris de Graaf, Niels J Hauwert, Lisa M Wijnen
Publikováno v:
Journal of the American Chemical Society, 140(12), 4232-4243. American Chemical Society
Journal of the American Chemical Society
Hauwert, N J, Mocking, T A M, Da Costa Pereira, D, Kooistra, A J, Wijnen, L M, Vreeker, G C M, Verweij, E W E, De Boer, A H, Smit, M J, De Graaf, C, Vischer, H F, De Esch, I J P, Wijtmans, M & Leurs, R 2018, ' Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology ', Journal of the American Chemical Society, vol. 140, no. 12, pp. 4232-4243 . https://doi.org/10.1021/jacs.7b11422
Journal of the American Chemical Society
Hauwert, N J, Mocking, T A M, Da Costa Pereira, D, Kooistra, A J, Wijnen, L M, Vreeker, G C M, Verweij, E W E, De Boer, A H, Smit, M J, De Graaf, C, Vischer, H F, De Esch, I J P, Wijtmans, M & Leurs, R 2018, ' Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology ', Journal of the American Chemical Society, vol. 140, no. 12, pp. 4232-4243 . https://doi.org/10.1021/jacs.7b11422
Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2018770a8aaed1281f8d5546a396b84
https://research.vu.nl/en/publications/46de74ba-321e-4392-857e-fca565a84e37
https://research.vu.nl/en/publications/46de74ba-321e-4392-857e-fca565a84e37
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493968411
The H4R is the latest addition of the histamine receptor family. This GPCR was found to be involved in a multitude of allergic and inflammatory diseases. Antagonizing H4Rs results in profound anti-inflammatory effects in various animal disease models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c5f422da40be0ef3cbcdac90b7b9f7
https://doi.org/10.1007/978-1-4939-6843-5_6
https://doi.org/10.1007/978-1-4939-6843-5_6