Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Autor: Julia Böhme, Nuria Martinez, Shamin Li, Andrea Lee, Mardiana Marzuki, Anteneh Mehari Tizazu, David Ackart, Jessica Haugen Frenkel, Alexandra Todd, Ekta Lachmandas, Josephine Lum, Foo Shihui, Tze Pin Ng, Bernett Lee, Anis Larbi, Mihai G. Netea, Randall Basaraba, Reinout van Crevel, Evan Newell, Hardy Kornfeld, Amit Singhal

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+

Externí odkaz: https://doaj.org/article/c3eaedfff37a462ea0ead94e00336a91

Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids

Autor: Ekta Lachmandas, Corina N. A. M. van den Heuvel, Michelle S. M. A. Damen, Maartje C. P. Cleophas, Mihai G. Netea, Reinout van Crevel

Publikováno v: Journal of Diabetes Research, Vol 2016 (2016)

Type 2 diabetes mellitus confers a threefold increased risk for tuberculosis, but the underlying immunological mechanisms are still largely unknown. Possible mediators of this increased susceptibility are short-chain fatty acids, levels of which have

Externí odkaz: https://doaj.org/article/975ad265140f493393de877701c0b023

The role of glutamine metabolism for host defense against Mycobacterium tuberculosis infection

Autor: Mihai G. Netea, Reinout van Crevel, Ekta Lachmandas, Marije Oosting, Valerie A. C. M. Koeken, Vinod Kumar, Leo A. B. Joosten, Anca Riza, Vasiliki Matzaraki, Yang Li

Publikováno v: The Journal of Infectious Diseases, 219, 1662-1670
The Journal of Infectious Diseases, 219(10), 1662-1670. Oxford University Press
The Journal of Infectious Diseases, 219, 10, pp. 1662-1670

Contains fulltext : 206797.pdf (Publisher’s version ) (Closed access) BACKGROUND: Rewiring cellular metabolism is important for activation of immune cells during host defense against Mycobacterium tuberculosis. Glutamine has been implicated as an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5173634483243091c8e4781563d81391
https://hdl.handle.net/11370/eea1a56c-8cd1-4df2-87a1-0c610d718a4d

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Autor: Josephine Lum, David F. Ackart, Amit Singhal, Andrea H. Lee, Tze Pin Ng, Anis Larbi, Mihai G. Netea, Bernett Lee, Mardiana Marzuki, Alexandra Todd, Jessica Haugen Frenkel, Anteneh Mehari Tizazu, Nuria Martinez, Randall J. Basaraba, Shamin Li, Evan W. Newell, Reinout van Crevel, Julia Böhme, Ekta Lachmandas, Foo Shihui, Hardy Kornfeld

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11, 1
Nature Communications
Nature Communications, 11

Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37162fecfb7ac3021cf5aff5a400feb1
https://doi.org/10.1038/s41467-020-19095-z

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein

Autor: Kathrin Thiem, Yang Li, Rinke Strienstra, Charlotte D C C van der Heijden, Marije Oosting, Janna A. van Diepen, Siroon Bekkering, Vera P. Mourits, Trees Jansen, Valerie A. C. M. Koeken, Reinout van Crevel, Mihai G. Netea, Niels P. Riksen, L. Charlotte J. de Bree, Hendrik G. Stunnenberg, Ekta Lachmandas, Leo A. B. Joosten, Laszlo Groh, Samuel T. Keating, Vasiliki Matzaraki, Jelmer H. van Puffelen, Boris Novakovic, Simone J.C.F.M. Moorlag

Publikováno v: Journal of Molecular Medicine, 98(6), 819-831. SPRINGER HEIDELBERG
J Mol Med (Berl)
Keating, S T, Groh, L, Thiem, K, Bekkering, S, Li, Y, Matzaraki, V, van der Heijden, C D C C, van Puffelen, J H, Lachmandas, E, Jansen, T, Oosting, M, de Bree, L C J, Koeken, V A C M, Moorlag, S J C F M, Mourits, V P, van Diepen, J, Strienstra, R, Novakovic, B, Stunnenberg, H G, van Crevel, R, Joosten, L A B, Netea, M G & Riksen, N P 2020, ' Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein ', Journal of Molecular Medicine, vol. 98, no. 6, pp. 819-831 . https://doi.org/10.1007/s00109-020-01915-w
Journal of Molecular Medicine-Jmm, 98, 819-831
Journal of Molecular Medicine-Jmm, 98, 6, pp. 819-831
Journal of Molecular Medicine 98 (2020)
Journal of Molecular Medicine, 98, 819-831
Journal of Molecular Medicine (Berlin, Germany)

Abstract Stimulation of monocytes with microbial and non-microbial products, including oxidized low-density lipoprotein (oxLDL), induces a protracted pro-inflammatory, atherogenic phenotype sustained by metabolic and epigenetic reprogramming via a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bb5b5583dff28e66ce928c9a32be99
https://research.rug.nl/en/publications/2f140765-cb06-4e6d-908e-8e311dc93b87