Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ekta Kadakia"'
Autor:
Arijit Chakravarty, Karthik Venkatakrishnan, Rachael Brake, Natasha Iartchouk, Rachel Neuwirth, Chirag Patel, Jilai Zhou, Ekta Kadakia, Mayankbhai Patel, Dean C. Bottino
Supplementary Methods, Figures S1-5, and Tables S1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b088fa39511bd74eaedb270218472df5
https://doi.org/10.1158/1078-0432.22472366
https://doi.org/10.1158/1078-0432.22472366
Autor:
Arijit Chakravarty, Karthik Venkatakrishnan, Rachael Brake, Natasha Iartchouk, Rachel Neuwirth, Chirag Patel, Jilai Zhou, Ekta Kadakia, Mayankbhai Patel, Dean C. Bottino
Purpose:Recommended phase II dose (RP2D) determination for combination therapy regimens is a constrained optimization problem of maximizing antitumor activity within the constraint of clinical tolerability to provide a wide therapeutic index. A metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1697e4d2a6132b6b742a4af840721a2e
https://doi.org/10.1158/1078-0432.c.6528203.v1
https://doi.org/10.1158/1078-0432.c.6528203.v1
Autor:
Mansoor M. Amiji, Anupama Rajanbabu, Keechilat Pavithran, Smrithi Padmakumar, Shantikumar V. Nair, D K Vijaykumar, Thangalazhi Balakrishnan Sivanarayanan, Bindhu Paul-Prasanth, Ekta Kadakia, Deepthy Menon
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 15:274-284
A woven nanotextile implant was developed and optimized for long-term continuous drug delivery for potential oncological applications. Electrospun polydioxanone (PDS) nanoyarns, which are twisted bundles of PDS nanofibres, were loaded with paclitaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e333830e2217a6420db8d5d284ebfe3
https://doi.org/10.1016/j.nano.2018.10.002
https://doi.org/10.1016/j.nano.2018.10.002
Publikováno v:
Expert opinion on drug delivery. 17(3)
Introduction: Neurodegenerative diseases are those wherein the neurons in the brain or peripheral nervous system lose their function, eventually culminating in neuronal death. Aging acts as the predominant factor here due to the reduced protein turno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c647664fdc195b8cee0b7f0cea3d9c
https://pubmed.ncbi.nlm.nih.gov/32027807
https://pubmed.ncbi.nlm.nih.gov/32027807
Publikováno v:
Pharmaceutical Research. 34:1416-1427
Nanoemulsions have shown potential in delivering drug across epithelial and endothelial cell barriers, which express efflux transporters. However, their transport mechanisms are not entirely understood. Our goal was to investigate the cellular permea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7bbd049d14c7bd810d40ea0686d493
https://doi.org/10.1007/s11095-017-2158-7
https://doi.org/10.1007/s11095-017-2158-7
Publikováno v:
Pharmaceutical research. 36(9)
Despite extensive preclinical investigations, in-vivo properties and formulation characteristics that improve CNS drug delivery following systemic dosing of nanoemulsions remain incompletely understood.The CNS targeting potential of systemically admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76fa161d408bba774162bf28ade7e42
https://pubmed.ncbi.nlm.nih.gov/31297653
https://pubmed.ncbi.nlm.nih.gov/31297653
Publikováno v:
Pharmaceutical Research. 36
Despite encouraging preclinical results, mechanisms of CNS drug delivery following intranasal dosing of nanoemulsions remain incompletely understood. Herein, the transport characteristics of intranasally administered nanoemulsions are investigated us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3902ada76e2dce7afb32463b35b82d
https://doi.org/10.1007/s11095-019-2610-y
https://doi.org/10.1007/s11095-019-2610-y
Autor:
Rachael L. Brake, Dean Bottino, Ekta Kadakia, Mayankbhai Patel, Jilai Zhou, Karthik Venkatakrishnan, Natasha Iartchouk, Arijit Chakravarty, Chirag Patel, Rachel Neuwirth
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(22)
Purpose: Recommended phase II dose (RP2D) determination for combination therapy regimens is a constrained optimization problem of maximizing antitumor activity within the constraint of clinical tolerability to provide a wide therapeutic index. A meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0145b86657550dbb40690fa8f1b22925
https://pubmed.ncbi.nlm.nih.gov/31515459
https://pubmed.ncbi.nlm.nih.gov/31515459
Autor:
Ekta Kadakia, Natasha Iartchouk, Karuppiah Kannan, Keli Song, Dong Mei Zhang, Christopher Zopf, Munjal Patel, Chirag Patel, Swapan Chowdhury, Wen Chyi Shyu, Jing-Tao Wu, Arijit Chakravarty
Publikováno v:
Molecular Cancer Therapeutics. 14:B154-B154
During preclinical development of investigational compound, MLN1117, combination efficacy studies of MLN1117 and Taxotere in mice bearing lung cancer tumor xenografts indicated the presence of a scheduling effect. In many instances, pre-dosing Taxote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::764c251229c10876807b8c80e8ebcd80
https://doi.org/10.1158/1535-7163.targ-15-b154
https://doi.org/10.1158/1535-7163.targ-15-b154