Disturbed Presynaptic Ca2+ Signaling in Photoreceptors in the EAE Mouse Model of Multiple Sclerosis

Autor: Amrita Mukherjee, Rashmi Katiyar, Ekta Dembla, Mayur Dembla, Praveen Kumar, Anouar Belkacemi, Martin Jung, Andreas Beck, Veit Flockerzi, Karin Schwarz, Frank Schmitz

Publikováno v: iScience, Vol 23, Iss 12, Pp 101830- (2020)

Summary: Multiple sclerosis (MS) is a demyelinating disease caused by an auto-reactive immune system. Recent studies also demonstrated synapse dysfunctions in MS patients and MS mouse models. We previously observed decreased synaptic vesicle exocytos

Externí odkaz: https://doaj.org/article/2347bc37190e414885db72c0df12eefa

The Calcineurin-Binding, Activity-Dependent Splice Variant Dynamin1xb Is Highly Enriched in Synapses in Various Regions of the Central Nervous System

Autor: Marie-Lisa Eich, Ekta Dembla, Silke Wahl, Mayur Dembla, Karin Schwarz, Frank Schmitz

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb. Calcineurin is a Ca2+-regulated phosphatase that enhances dynamin1 ac

Externí odkaz: https://doaj.org/article/e70411b52cc945edbb835cc82f0d2da6

Early Changes in Exo- and Endocytosis in the EAE Mouse Model of Multiple Sclerosis Correlate with Decreased Synaptic Ribbon Size and Reduced Ribbon-Associated Vesicle Pools in Rod Photoreceptor Synapses

Autor: Karin Schwarz, Ekta Dembla, Mayur Dembla, Ajay Kesharwani, Frank Schmitz

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10789, p 10789 (2021)

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that finally leads to demyelination. Demyelinating optic neuritis is a frequent symptom in MS. Recent studies also revealed synapse dysfunctions in MS patients and MS mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b3d43eb8bdf2a28caea1b26263e421
https://pubmed.ncbi.nlm.nih.gov/34639129

Author response for 'Biogenesis of large dense core vesicles in mouse chromaffin cells'

Autor: Ekta Dembla, Ute Becherer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9783ebd658a553f19bb0406b63876a7e
https://doi.org/10.1111/tra.12783/v3/response1

Deciphering Dead-End Docking of Large Dense Core Vesicles in Bovine Chromaffin Cells

Autor: Ekta Dembla, Mahantappa Halimani, Ulf Matti, Jens Rettig, Sandra Hugo, Ute Becherer

Large dense core vesicle (LDCV) exocytosis in chromaffin cells follows a well characterized process consisting of docking, priming, and fusion. Total internal reflection fluorescence microscopy (TIRFM) studies suggest that some LDCVs, although being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d51509214153db6de374975f878d14
https://europepmc.org/articles/PMC6618444/