Selective biologics for ulcerative colitis and Crohn's disease – clinical utility of vedolizumab

Autor: Petkau JM, Eksteen B

Publikováno v: Biologics: Targets & Therapy, Vol 2016, Iss Issue 1, Pp 33-52 (2016)

Jill MV Petkau, Bertus Eksteen Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Abstract: Inflammatory bowel disease (IBD) encompasses a cluster of different disease phenotypes which are br

Externí odkaz: https://doaj.org/article/16d54277c0ca45cd9a766de82cb513b8

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

Autor: Weismueller, T, Strassburg, C, Trivedi, P, Hirschfield, G, Bergquist, A, Said, K, Imam, M, Lazaridis, K, Juran, B, Cheung, A, Lindor, K, Lenzen, H, Manns, M, Ponsioen, C, Beuers, U, Holm, K, Naess, S, Karlsen, T, Schrumpf, E, Boberg, K, Gotthardt, D, Rupp, C, Faerkkilae, M, Jokelainen, K, Marschall, H, Benito De Valle, M, Thorburn, D, Saffioti, F, Weersma, R, Fevery, J, Mueller, T, Chazouillãres, O, Schulze, K, Schramm, C, Almer, S, Pereira, S, Levy, C, Mason, A, Bowlus, C, Floreani, A, Halilbasic, E, Trauner, M, Yimam, K, Milkiewicz, P, Huynh, D, Pares, A, Manser, C, Dalekos, G, Eksteen, B, INVERNIZZI, PIETRO, Berg, C, Kirchner, G, Sarrazin, C, Zimmer, V, Fabris, L, Braun, F, Marzioni, M, Chapman, R, Hansen, B, Hansen, B.

Publikováno v: Gastroenterology, 152(8), 1975-1984.e8. W.B. Saunders Ltd
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Gastroenterology, 152(8), 1975-+. W.B. Saunders
Gastroenterology, 152(8), 1975-1984. W B SAUNDERS CO-ELSEVIER INC

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large intern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1873b2be5a096673b674a59e39b8c4c
https://doi.org/10.1053/j.gastro.2017.02.038

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

Autor: Henriksen, EKK, Viken, MK, Wittig, M, Holm, K, Folseraas, T, Mucha, S, Melum, E, Hov, JR, Lazaridis, KN, Juran, BD, Chazouillères, O, Färkkilä, M, Gotthardt, DN, Invernizzi, P, Carbone, M, Hirschfield, GM, Rushbrook, SM, Goode, E, UK-PSC Consortium, Ponsioen, CY, Weersma, RK, Eksteen, B, Yimam, KK, Gordon, SC, Goldberg, D, Yu, L, Bowlus, CL, Franke, A, Lie, BA, Karlsen, TH

Publikováno v: HLA, vol 90, iss 4

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8659da7c5aec11bb61dd5bbb2379e241
https://escholarship.org/uc/item/5cr1s258

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

Autor: Oo, YH, Banz, V, Kavanagh, D, Liaskou, E, Withers, DR, Humphreys, E, Reynolds, GM, Lee-Turner, L, Kalia, N, Hubscher, SG, Klenerman, P, Eksteen, B, Adams, DH

Background and Aims: IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown. Methods: The phenotype and migra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8e4ed0061bc084a0c224bf545c835d56
https://doi.org/10.1016/j.jhep.2012.07.008

Cholangiocyte chemokine secretion and macrophage accumulation is mediated by osteopontin in murine liver models

Autor: Coombes, J. D., Manka, P. P., Swiderska-Syn, M., Reid, D., Riva, A., Claridge, L. C., Dolle, L., Younis, R., Briones, M. A., Kitamura, N., Mehta, K., Mi, Z. Y., Kuo, P. C., Williams, R., Diehl, A. M., van Grunsven, L. A., Chokshi, S., Canbay, Aliekber, Flamant, F., Gauthier, K., Eksteen, B., Syn, W. K.

Publikováno v: 67. Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016
67. Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, 2016, NA, France. pp.89A-90A
Hepatology

Background and aims Progression of chronic liver disease involves accumulation of inflammatory cells towards the peri-portal regions during a ductular inflammatory response. Osteopontin (OPN), an effector of Hh signalling, contributes to liver fibrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47aef92acd099d72867c739f421b5d3e
https://hal.archives-ouvertes.fr/hal-01602927