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Abstract P2-05-03: Role of tumor immune environment in tumor initiation and growth rates in mouse mammary tumor models

Autor: Mary L. Disis, Ekram Gadd, Marlese Koehnlein, Piper M. Treuting, Sasha E. Stanton, Lauren Rastetter, Meredith Slota

Publikováno v: Cancer Research. 73:P2-05

The role of the tumor immune environment is critical in human breast cancer tumorigenesis and response to therapy: tumors with a Th1 immune activating environment (high cytotoxic CD8+ T cells and low FoxP3 and myeloid derived suppressor cells (MDSC))

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1998b028f77e1a903495edca891d9a00
https://doi.org/10.1158/0008-5472.sabcs13-p2-05-03

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Abstract 1352: Identifying pre-diagnostic breast cancer antigens in transgenic mouse mammary tumor models for preventative vaccine development

Autor: Sasha E. Stanton, Jianning Mao, James Annis, Mary L. Disis, Samir M. Hanash, Lauren Rastetter, John Ladd, Ekram Gadd

Publikováno v: Cancer Research. 75:1352-1352

Preventative vaccine therapy may benefit women at high risk for breast cancer but currently it is impossible to identify women who will develop breast cancer prior to tumor development to identify initiating cancer antigens. Immunocompetent transgeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::094c087045c146cffe0e4f098abcee3d
https://doi.org/10.1158/1538-7445.am2015-1352

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Abstract 279: Bexarotene increases tumor CD8+ T cells and improves response to conventional breast chemotherapy in the transgenic mouse mammary tumor model TgMMTV-neu

Autor: Lauren Rastetter, Sasha E. Stanton, Edmond Marzbani, Mary L. Disis, Ekram Gadd

Publikováno v: Cancer Research. 75:279-279

In breast cancer, increased immune infiltrate prior to neoadjuvant chemotherapy predicts improved pathologic complete response (pCR) and improved survival, however almost half of breast tumors have no CD8+ T cell infiltrate. Evidence has emerged that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68beb88ec66dda7a08638ab4d39b8084
https://doi.org/10.1158/1538-7445.am2015-279

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Abstract P5-01-09: Early tumor antigens discovered in TgMMTV-neu mice may provide targets for early breast cancer diagnosis and prevention

Autor: Sasha E. Stanton, Mary L. Disis, Lauren Rastetter, Jon Ladd, Samir M. Hanash, Jianning Mao, Ekram Gadd

Publikováno v: Cancer Research. 73:P5-01

Breast cancer is immunogenic and breast tumor proteins stimulate both an antibody and a T cell immune response. Identification of cancer related proteins that become immunogenic prior to the clinical development of cancer may allow the use of humoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd54757e934c1dfbb223813a86755e96
https://doi.org/10.1158/0008-5472.sabcs13-p5-01-09

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