Iodine-125-labeled DNA-Triplex-forming oligonucleotides reveal increased cyto- and genotoxic effectiveness compared to Phosphorus-32

Autor: Ekkehard Pomplun, Volker Dahmen, Ralf Kriehuber

Publikováno v: International journal of radiation biology 92(11), 679-685 (2016). doi:10.3109/09553002.2016.1160157

PURPOSE: The efficacy of DNA-targeting radionuclide therapies might be strongly enhanced by employing short range particle-emitters. However, the gain of effectiveness is not yet well substantiated. We compared the Auger electron emitter I-125 to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1b6bbe22fbf70dc35911002e5106ce
https://hdl.handle.net/2128/16240

Chromosome aberrations induced by the Auger electron emitter 125I

Autor: Ralf Kriehuber, Dominik Oskamp, Sabine Schmitz, Ekkehard Pomplun

Publikováno v: Mutation research / Genetic toxicology and environmental mutagenesis 793, 64-70 (2015). doi:10.1016/j.mrgentox.2015.08.007 special issue: "Insights into formation and consequences of chromosome aberrations: Report on the 11th International Symposium on Chromosomal Aberrations (ISCA 11)"

DNA-associated Auger electron emitters (AEE) cause cellular damage leading to high-LET type cell survival curves indicating an enhanced relative biological effectiveness. Double strand breaks (DSBs) induced by Iodine-125-deoxyuridine ((125)I-UdR) dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd949bdcb1c30950be9e02d7561e6552
https://hdl.handle.net/2128/15333

Track Structures and Dose Distributions from Decays of131I and125I in and around Water Spheres Simulating Micrometastases of Differentiated Thyroid Cancer

Autor: Peter Jacob, Wei Bo Li, Christoph Reiners, Ekkehard Pomplun, Werner Friedland, Herwig G. Paretzke, Michael Lassmann

Publikováno v: Radiation Research. 156:419-429

The disintegration of the radionuclides (131)I and (125)I and the subsequent charged-particle tracks left behind in water (as a model substance for a biological cell) are simulated by the Monte Carlo track structure simulation code PARTRAC, using new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8505e20bedd3a599235a2c8741a187
https://doi.org/10.1667/0033-7587(2001)156[0419:tsaddf]2.0.co

Modelling of Initial Events and Chemical Behaviour of Species Induced in DNA Units by Auger Electrons from125I,123I and Carbon

Autor: M. Terrissol, Ekkehard Pomplun, Mathilde Demonchy

Publikováno v: Acta Oncologica. 35:857-862

Auger electron spectra for 123I and 125I generated by Monte Carlo calculation and Auger electrons emitted from carbon after photoelectric effect on its K-shell as well as two DNA models (linear plasmid and nucleosome model) based on x-ray diffraction

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https://doi.org/10.3109/02841869609104037

Monte Carlo simulation of Auger electron cascades versus experimental data

Autor: Ekkehard Pomplun

Publikováno v: Biomedical Physics & Engineering Express. 2:015014

To further validate a Monte Carlo simulation code for Auger electron cascades, K-shell transitions in decaying 55Fe, 111In and 125I should be studied and compared with experimentally obtained spectra from the literature. The code used transition prob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::242d63f15b0a22f2ae05d66d6d527457
https://doi.org/10.1088/2057-1976/2/1/015014