Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Ekkehard May"'
1
Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate
Autor: Markus Berger, Heike Schäcke, Hartmut Rehwinkel, Stefan Jaroch, Ekkehard May, Roland Neuhaus, Thomas M. Zollner, Antje Rottmann
Publikováno v: Bioorganicmedicinal chemistry letters. 30(16)
We report on the discovery of the new clinical candidate BAY 1003803 as glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis. In the course of optimizing the amino alcohol series as a highly potent new no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b9f1da763597d6cfc37a5c916d55e0
https://pubmed.ncbi.nlm.nih.gov/32631518
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2
Adverse Skin Reactions to Iodinated X-ray Contrast Agents in Healthy Rats
Autor: Wolfram Haider, Hubertus Pietsch, Gregor Jost, Christine Morgenroth, Ekkehard May, Diana C. Lenhard
Publikováno v: Investigative Radiology. 49:779-787
Purpose The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomeric and 2 dimeric iodinated nonionic contra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6df464c73dc3cc471acd589a58ea90
https://doi.org/10.1097/rli.0000000000000084
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3
Immunomodulation by a novel, dissociated Vitamin D3analogue
Autor: Andreas Steinmeyer, Ekkehard May, Ulrich Zügel, Khusru Asadullah, Manfred Lehmann
Publikováno v: Experimental Dermatology. 18:619-627
The biologically active metabolite of vitamin D3, 1alpha,25-dihydroxyvitamin D3, has potent immunomodulatory activity; however, its clinical use is limited because of its hypercalcaemic activity in anti-inflammatory active doses. Here, we present ZK2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd2b5bf6f558460773d452cf894c6520
https://doi.org/10.1111/j.1600-0625.2009.00845.x
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4
Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases
Autor: Wolf-Dietrich Döcke, Hartmut Rehwinkel, Roland Neuhaus, Werner Skuballa, Khusru Asadullah, U Zügel, Ekkehard May, Stefan Jaroch, Heike Schäcke, Thomas M. Zollner
Publikováno v: British Journal of Pharmacology. 158:1088-1103
Background and purpose: Glucocorticoids are highly effective in the therapy of inflammatory diseases. Their value, however, is limited by side effects. The discovery of the molecular mechanisms of the glucocorticoid receptor and the recognition that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ee0adfb46870e725a8f594379137db1
https://doi.org/10.1111/j.1476-5381.2009.00238.x
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7
Immunoregulation Through 1,25-Dihydroxyvitamin D 3 and its Analogs
Autor: Ulrich Zügel, Ekkehard May, Khusru Asadullah
Publikováno v: Current Drug Target -Inflammation & Allergy. 3:377-393
Beyond its effects on bone metabolism, calcium and phosphorus homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3), calcitriol) exerts profound effects on the immune system. We here provide an overview over the metabolism, molecular and cellular ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b601b0a7a8425726f1560e2d45a180a1
https://doi.org/10.2174/1568010042634596
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8
HLA-B27 in Transgenic Rats Forms Disulfide-Linked Heavy Chain Oligomers and Multimers That Bind to the Chaperone BiP
Autor: Tri M. Tran, Martha L. Dorris, Ekkehard May, Eiichi Furuta, Nimman Satumtira, Andrew Z. Wang, Joel D. Taurog
Publikováno v: The Journal of Immunology. 172:5110-5119
To test the hypothesis that HLA-B27 predisposes to disease by forming disulfide-linked homodimers, we examined rats transgenic for HLA-B27, mutant Cys67Ser HLA-B27, or HLA-B7. In splenic Con A blasts from high transgene copy B27 lines that develop in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb943692c8b42ff1d4d21eea601c0842
https://doi.org/10.4049/jimmunol.172.8.5110
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9
T cell receptor δ repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping
Autor: Wolfgang F. Caspary, Andreas Hennemann, Wolfgang Holtmeier, Rainer Duchmann, Ekkehard May
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 282:G1024-G1034
Gamma/delta T cells might play an important role in autoimmune conditions like inflammatory bowel disease (IBD). In the present study, we characterized the T cell receptor (TCR)-delta repertoire by complementarity determining region 3 (CDR3) spectrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048fbb7d6a6d6f9496e04d5f29d062a3
https://doi.org/10.1152/ajpgi.00224.2001
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10
Immunomodulation by a novel, dissociated Vitamin D analogue
Autor: Ulrich, Zügel, Andreas, Steinmeyer, Ekkehard, May, Manfred, Lehmann, Khusru, Asadullah
Publikováno v: Experimental dermatology. 18(7)
The biologically active metabolite of vitamin D3, 1alpha,25-dihydroxyvitamin D3, has potent immunomodulatory activity; however, its clinical use is limited because of its hypercalcaemic activity in anti-inflammatory active doses. Here, we present ZK2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d5e182ba358ce61650cf0b0839b9689
https://pubmed.ncbi.nlm.nih.gov/19239489
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