Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ekkehard Mössner"'
Autor:
Christian Jost, Diana Darowski, John Challier, Vesna Pulko, Lydia J Hanisch, Wei Xu, Ekkehard Mössner, Alexander Bujotzek, Stefan Klostermann, Pablo Umana, Roland E. Kontermann, Christian Klein
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and bivalent binding to tumor-associated antigens in order to recruit and activate T-cells for t
Externí odkaz:
https://doaj.org/article/c938f861278d4a2aa878e6f0906f8d3a
Autor:
Sylvia Herter, Frank Herting, Gunter Muth, Erwin van Puijenbroek, Tilman Schlothauer, Claudia Ferrara, Kevin Brady, Sabine Lang, Marina Bacac, Ekkehard Mössner, Pablo Umana, Christian Klein
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/4b8ecb72c15b41bd871ce9af5bd9fcde
Autor:
Ekkehard Mössner, Andreas Plückthun
Publikováno v:
CHIMIA, Vol 55, Iss 4 (2001)
Directed molecular evolution has proven to be a very powerful concept for the generation of proteins with improved properties, such as increased activity, binding affinity, folding efficiency or enhanced chemical and/or thermodynamic stability. We re
Externí odkaz:
https://doaj.org/article/e820a7e9ec84483fa0ec96dc3a67588c
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Supplementary information on cell maintenance, and antibody selection and characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e363db33bfb70119118f019496cf74f
https://doi.org/10.1158/1535-7163.22507438.v1
https://doi.org/10.1158/1535-7163.22507438.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
FAP-drozitumab antibody-mediated apoptosis does not correlate with DR5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3902da6fa0a7fedce1633f385c71997d
https://doi.org/10.1158/1535-7163.22507435.v1
https://doi.org/10.1158/1535-7163.22507435.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Characterization and optimization of RG7386 dosing in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce9ad07c4aa7036fe31ed07f7a16bea
https://doi.org/10.1158/1535-7163.22507444.v1
https://doi.org/10.1158/1535-7163.22507444.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Dysregulated cellular apoptosis and resistance to cell death are hallmarks of neoplastic initiation and disease progression. Therefore, the development of agents that overcome apoptosis dysregulation in tumor cells is an attractive therapeutic approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494461f0b5e8179b32511522a796418b
https://doi.org/10.1158/1535-7163.c.6538687.v1
https://doi.org/10.1158/1535-7163.c.6538687.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Figure S2. Related to Figure 3. In vitro characterization of the FAP-DR5 BsAb RG7386; Table S4. Characterization of RG7386 binding avidities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3801c0935929b8b4a51298f3d1fcd860
https://doi.org/10.1158/1535-7163.22507447.v1
https://doi.org/10.1158/1535-7163.22507447.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Figure S1. Related to Figure 1. Characterization of FAP-drozitumab BsAbs and antitumor efficacy in the presence of FAP-expressing fibroblasts in in vitro co-culture models; Table S1. BsAb binding to DR5 and FAP antigens; Table S2. Anti-tumor efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c056f1250abf60294a4b98b6735ea39
https://doi.org/10.1158/1535-7163.22507450.v1
https://doi.org/10.1158/1535-7163.22507450.v1
Autor:
John Challier, Lydia Jasmin Hanisch, Ekkehard Mössner, Diana Darowski, Wei Xu, Christian Jost, Alexander Bujotzek, Roland E. Kontermann, Pablo Umana, Christian Klein, Vesna Pulko, Stefan Klostermann
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and bivalent binding to tumor-associated antigens in order to recruit and activate T-cells for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b8dd7e8bafef97b7b999e60412af7b
http://europepmc.org/articles/PMC7646475
http://europepmc.org/articles/PMC7646475